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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

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Volume 58, Issue 5


Volume 57 (2012)

Heart valve engineering: decellularized allograft matrices in clinical practice

Anneke Neumann
  • Department of Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Serghei Cebotari
  • Department of Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Igor Tudorache
  • Department of Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Axel Haverich
  • Department of Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany
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  • De Gruyter OnlineGoogle Scholar
/ Samir Sarikouch
  • Corresponding author
  • Department of Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Hanover, Germany
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
Published Online: 2013-05-28 | DOI: https://doi.org/10.1515/bmt-2012-0115


The purpose of this review is to update the current clinical experience with tissue-engineered, nonseeded, allogenic matrices for pulmonary and aortic valve replacement. Allogenic heart valve replacement using an aortic root homograft was first performed 50 years ago on July 24, 1962, by Donald Ross at Guy’s Hospital, London. Cryopreserved homografts have been the gold standard for many years in selected indications such as for pulmonary valve replacement in congenital heart disease, severe bacterial endocarditis, or for right ventricular outflow tract reconstruction during the Ross pulmonary autograft operation. However, there is evolving evidence that tissue-engineered decellularized homografts may be superior to conventional cryopreserved homografts.

Keywords: allogenic; artificial; heart valve replacement; matrices; scaffolds; tissue engineering


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About the article

Corresponding author: PD Dr. med. Samir Sarikouch, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hanover Medical School, Carl-Neuberg-Straße 1, 30625 Hanover, Germany, Phone: +49-511-532-5567, Fax: +49-511-532-18502, E-mail:

Received: 2012-12-13

Accepted: 2013-05-13

Published Online: 2013-05-28

Published in Print: 2013-10-01

Citation Information: Biomedizinische Technik/Biomedical Engineering, Volume 58, Issue 5, Pages 453–456, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2012-0115.

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