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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /

IMPACT FACTOR 2017: 1.096
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Volume 62, Issue 2


Volume 57 (2012)

Comparison of novel physiological load-adaptive control strategies for ventricular assist devices

Moriz Habigt
  • Corresponding author
  • Department of Anaesthesiology, University Hospital RWTH Aachen, Pauwelsstr. 30, 52074 Aachen, Germany, Phone: +49 80 88179
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Maike Ketelhut / Jonas GesenhuesORCID iD: http://orcid.org/0000-0003-4476-8727 / Frank Schrödel / Marc Hein / Mare Mechelinck / Thomas Schmitz-Rode / Dirk Abel / Rolf Rossaint
Published Online: 2016-11-17 | DOI: https://doi.org/10.1515/bmt-2016-0073


Terminal heart failure (HF) is the most prevalent cause of death in the Western world and the implantation of a left ventricular assist device (LVAD) has become the gold standard therapy today. Most of the actually implanted devices are driven at a constant speed (CS) regardless of the patient’s physiological demand. A new physiological controller [power ratio (PR) controller], which keeps a constant ratio between LVAD power and left ventricular power, a previous concept [preload responsive speed (PRS) controller], which adds a variable LVAD power to reach a defined stroke work, and a CS controller were compared with an unimpaired ventricle in a full heart computer simulation model. The effects of changes in preload, afterload and left ventricular contractility are displayed by global hemodynamics and ventricular pressure-volume loops. Both physiological controllers demonstrated the desired load dependency, whereas the PR controller exceeded the PRS controller in response to an increased load and contractility. Response was inferior when preload or contractility was decreased. Thus, the PR controller might lead to an increased exercise tolerance of the patient. Additional studies are required to evaluate the controllers in vivo.

Keywords: cardiovascular simulation model; physiological controller; preload recruitable stroke work; ventricular assist device; ventricular unloading


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About the article

Received: 2016-03-21

Accepted: 2016-09-29

Published Online: 2016-11-17

Published in Print: 2017-04-01

Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 62, Issue 2, Pages 149–160, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2016-0073.

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