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Biomedical Engineering / Biomedizinische Technik

Joint Journal of the German Society for Biomedical Engineering in VDE and the Austrian and Swiss Societies for Biomedical Engineering and the German Society of Biomaterials

Editor-in-Chief: Dössel, Olaf

Editorial Board: Augat, Peter / Habibović, Pamela / Haueisen, Jens / Jahnen-Dechent, Wilhelm / Jockenhoevel, Stefan / Knaup-Gregori, Petra / Lenarz, Thomas / Leonhardt, Steffen / Plank, Gernot / Radermacher, Klaus M. / Schkommodau, Erik / Stieglitz, Thomas / Boenick, Ulrich / Jaramaz, Branislav / Kraft, Marc / Lenthe, Harry / Lo, Benny / Mainardi, Luca / Micera, Silvestro / Penzel, Thomas / Robitzki, Andrea A. / Schaeffter, Tobias / Snedeker, Jess G. / Sörnmo, Leif / Sugano, Nobuhiko / Werner, Jürgen /


IMPACT FACTOR 2017: 1.096
5-year IMPACT FACTOR: 1.492

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1862-278X
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Volume 63, Issue 3

Issues

Volume 57 (2012)

Preparation, characterization and blood compatibility assessment of a novel electrospun nanocomposite comprising polyurethane and ayurvedic-indhulekha oil for tissue engineering applications

Manikandan Ayyar
  • Department of Chemistry, Bharath Institute of Higher Education and Research, Bharath University, Chennai 600073, Tamil Nadu, India
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Mohan Prasath Mani
  • IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Saravana Kumar Jaganathan
  • Corresponding author
  • IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, Universiti Teknologi Malaysia, Skudai 81300, Johor, Malaysia
  • Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam
  • Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
  • Email
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rajasekar Rathanasamy
Published Online: 2017-07-05 | DOI: https://doi.org/10.1515/bmt-2017-0022

Abstract

Electrospun polyurethane based nanocomposite scaffolds were fabricated by mixing with indhulekha oil. Scanning electron microscope (SEM) portrayed the nanofibrous nature of the composite and the average diameters of the composite scaffold were smaller than the pristine scaffolds. The fabricated scaffold was found to be hydrophobic (114°) due to the inclusion of indhulekha oil, which was displayed in contact angle measurement analysis. The fourier transform infrared spectroscopy (FTIR) results indicated that the indhulekha oil was dispersed in PU matrix identified by formation of hydrogen bond and peak shifting of CH group. The PU/indhulekha oil nanocomposite exhibits a higher decomposition onset temperature and also residual weight percentage at 900°C was more compared to the pure PU. Surface roughness was found to be increased in the composite compared to the pristine PU as indicated by the atomic force microscopy (AFM) analysis. In order to investigate the blood compatibility of electrospun nanocomposites the activated partial thromboplastin time (APTT) assay, prothrombin time (PT) assay and hemolytic assay were performed. The blood compatibility results APTT and PT revealed that the developed nanocomposites demonstrated delayed clotting time indicating the anticoagulant nature of the composite in comparison with the pristine PU. Further, it was also observed that the hemolytic index of nanocomposites was reduced compared to pure PU suggesting the non-hemolytic nature of the fabricated scaffold. Hence, the fabricated nanocomposites might be considered as a potent substitute for scaffolding damaged tissue due to their inherent physicochemical and blood compatibility properties.

Keywords: hemocompatibile; indhulekha oil; nanocomposites; polyurethane; tissue engineering

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About the article

Received: 2017-03-03

Accepted: 2017-05-24

Published Online: 2017-07-05

Published in Print: 2018-06-27


Author Statement

Research funding: This work was supported by the Ministry of Higher Education Malaysia with the Grant no. Q.J130000.2545.14H59.

Conflict of interest: Authors state no conflict of interest.

Informed consent: Informed consent is not applicable.

Ethical approval: The conducted research is not related to either human or animals use.


Citation Information: Biomedical Engineering / Biomedizinische Technik, Volume 63, Issue 3, Pages 245–253, ISSN (Online) 1862-278X, ISSN (Print) 0013-5585, DOI: https://doi.org/10.1515/bmt-2017-0022.

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