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Botanica Marina

Editor-in-Chief: Dring, Matthew J.

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1437-4323
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Volume 53, Issue 3 (Jun 2010)

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Anti-inflammatory, antioxidant and antimicrobial activities of aqueous and organic extracts from Dictyopteris membranacea

Zouhaier Ben Aoun
  • Unité de Recherche URSAM, Laboratoire de Pharmacologie, Faculté de Pharmacie de Monastir, Monastir, Tunisia
  • Unité de Contrôle des Médicaments, Laboratoire de Chimie Analytique, Faculté de Pharmacie de Monastir, Monastir, Tunisia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Rafik Ben Said / Farhat Farhat
  • Unité de Contrôle des Médicaments, Laboratoire de Chimie Analytique, Faculté de Pharmacie de Monastir, Monastir, Tunisia
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar

Abstract

Aqueous and organic extracts from Dictyopteris membranacea collected from the Tunisian Mediterranean coast were studied for their anti-inflammatory, antioxidant and anti-microbial activities. All extracts had high anti-inflammatory activity in carrageenan-induced rat paw edema assays in Wistar rats, and their effects are comparable to acetylsalicylate lysine (300 mg kg-1, applied intraperitoneally) used as a reference drug. Dictyopteris membranacea extracts had inhibition percentages in the third hour of the assay of 65% at a dose of 100 mg kg-1, 51% at a dose of 50 mg kg-1, and 49% at a dose of 100 mg kg-1 in aqueous, chloroform and ethyl acetate extracts, respectively. Chloroform and ethyl acetate extracts exhibited 2,2-diphenyl-1-picrylhydrazyl radical scavenging with IC50 values (0.089±0.01 and 0.11±0.02 mg ml-1, respectively) equivalent to the activity of a powerful antioxidant standard, Trolox (IC50=0.09±0.02 mg ml-1). These extracts (chloroform and ethyl acetate) had reducing activity, and the total phenol contents were: 84.96 and 60.96 mg gallic acid equivalent per gram dried sample, respectively. Organic extracts had moderate antimicrobial activity (using the disc diffusion method) against three bacteria: Staphylococcus aureus, Staphylococcus epidermidis and Micrococcus luteus, and four species of a fungal genus: Candida albicans, C. krusei, C. dubliniensis and C. kefyr at 10 mg per disc, whereas the aqueous extract exhibited significant antibacterial activity against only Staphylococcus aureus and Listeria monocytogenes.

Keywords: anti-inflammatory activity; antimicrobial activity; antioxidant activity; Dictyopteris membranacea

About the article

Corresponding author


Received: 2009-03-11

Accepted: 2010-02-01

Published in Print: 2010-06-01


Citation Information: Botanica Marina, ISSN (Online) 1437-4323, ISSN (Print) 0006-8055, DOI: https://doi.org/10.1515/BOT.2010.027.

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