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Botanica Marina

Editor-in-Chief: Dring, Matthew J.


IMPACT FACTOR 2018: 0.919
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1437-4323
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Volume 50, Issue 3

Issues

Antiviral activity of a sulfoquinovosyldiacylglycerol (SQDG) compound isolated from the green alga Caulerpa racemosa

Hui Wang / Yao-Lan Li
  • 2Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P.R. China
  • Other articles by this author:
  • De Gruyter OnlineGoogle Scholar
/ Wei-Zai Shen / Wen Rui / Xia-Jun Ma / Ying-Zhou Cen
Published Online: 2007-08-10 | DOI: https://doi.org/10.1515/BOT.2007.022

Abstract

An invasive green alga, Caulerpa racemosa, collected from the South China Sea was tested for its antiviral properties. Hot water extracts and the n-butanol fraction obtained showed potent inhibition of herpes simplex virus type 1 (HSV-1) and Coxsackie virus B3 (Cox B3). A sulfoquinovosyldiacylglycerol (SQDG) compound was isolated and purified from the n-butanol fraction following further antiviral-guided fractionation. The SQDG compound exhibited an excellent antiviral effect against HSV-2, with a 50% inhibitory concentration (IC50) of 15.6 μg ml-1 against both standard and clinical strains of HSV-2, but showed only moderate antiviral effects against HSV-1 and Cox B3. The SQDG compound was chemically characterized using spectroscopic methods as (2S)-1,2-di-O-palmitoyl-3-O-(6′-sulfo-α-D-quinovopyranosyl) glycerol. This is the first isolation from C. racemosa of this SQDG compound with notable selective antiviral activity against HSV-2.

Keywords: antiviral activity; Caulerpa racemosa; (2S)-1,2-di-O-palmitoyl-3-O-(6′-sulfo-α-D-quinovopyranosyl) glycerol; herpes simplex virus; SQDG

About the article

Corresponding author


Received: 2006-10-18

Accepted: 2007-06-20

Published Online: 2007-08-10

Published in Print: 2007-08-01


Citation Information: Botanica Marina, Volume 50, Issue 3, Pages 185–190, ISSN (Online) 14374323, ISSN (Print) 00068055, DOI: https://doi.org/10.1515/BOT.2007.022.

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