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Bulletin of the Veterinary Institute in Pulawy

The Journal of National Veterinary Research Institute in Pulawy

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Seminoma, Sertolioma, and Leydigoma in Dogs: Clinical and Morphological Correlations

Rafał Ciaputa
  • Corresponding author
  • Department of Pathology, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
  • Email:
/ Marcin Nowak
  • Department of Pathology, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
/ Maciej Kiełbowicz
  • Department of Surgery, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
/ Agnieszka Antończyk
  • Department of Reproduction and Clinic of Farm Animals, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
/ Karolina Błasiak
  • Department of Reproduction and Clinic of Farm Animals, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
/ Janusz A. Madej
  • Department of Pathology, Wroclaw University of Environmental and Life Sciences, 50-375 Wroclaw, Poland
Published Online: 2013-01-17 | DOI: https://doi.org/10.2478/v10213-012-0063-8

Abstract

The study aimed at presenting the most frequent male gonadal tumours in dogs, their clinical and histopathological aspects, at outlining aetiopathogenesis and differential diagnosis of the tumours. As examples of the most frequently manifested testicular tumours, three clinical cases were presented, involving tumour of interstitial (Leydig) cells, tumour of Sertoli cells, and seminoma. Respective clinical diagnosis employed USG, X-ray patterns, and morphological and biochemical tests. The surgically sampled material was stained with H+E and an attempt was made to establish expression of E-cadherin, calretinin, and Ki-67. It was shown that histopathological diagnosis of testicular tumours in dogs is frequently very difficult and complex and requires multidirectional studies.

Keywords: dogs; seminoma; sertolioma; leydigoma; calretinin; E-cadherin

  • 1. Barrand K.R., Scudamore C.L.: Canine hypertrophic osteoarthropathy associated with a malignant Sertoli cell tumour. J Small Anim Pract 2001, 42, 143-145. [PubMed] [Crossref]

  • 2. Bazzo R., Sarli G., Mandrioli L., Maecato P.S.: Sertoli cell tumour with Call-Exner-like bodies in a dog. J Vet Med A Physiol Pathol Clin Med 2002, 49, 535-537. [Crossref]

  • 3. Benazzi C., Sarli G., Brunetti B.: Sertoli cell tumour in a cat. J Vet Med A Physiol Pathol Clin Med 2004, 51, 124-126. [Crossref]

  • 4. Chaganti R.S.K., Houldsworth J.: Genetic and biology of adult human male germ cell tumors. Cancer Res 2000, 60, 1475-1482. [PubMed]

  • 5. Coupland C.A.C., Chilvers C.E.D., Davey G., Pike M.C., Oliver R.T.D., Forman D.: Risk factors for testicular germ cell tumours by histological tumour type. Br J Cancer 1999, 80, 1859-1863. [Crossref] [PubMed]

  • 6. Gawlik-Jakubczak T., Krajka K.: A case of nonseminomatous testis tumor. Przegl Lek 2004, 61, 528-534. Gorolla A., Terlin A., Vinanzi C., Roverato A., Sotti G., Antibani W., Foresta C.: Molecular analysis of the androgen receptor gene in testicular cancer. Endocr Relat Cancer 2005, 12, 645-655.

  • 7. Gorolla A., Terlin A., Vinanzi C., Roverato A., Sotti G., Antibani W., Foresta C.: Molecular analysis of the androgen receptor gene in testicular cancer. Endocr Relat Cancer 2005, 12, 645-655. [Crossref]

  • 8. Grieco V., Riccardi E., Greppi G.F., Teruzzi F., Iermano V., Finazzi M.: Canine testicular tumours: a study on 232 dogs. J Comp Path 2008, 138, 86-89.

  • 9. Hemminki K., Sweden L.X.: Familial risk in testicular cancer as a clue to heritable and environmental aetiology. Br J Cancer 2004, 90, 1765-1770. [Crossref] [PubMed]

  • 10. Highman W.J., Oliver R.T.D.: Diagnosis of metastases from testicular germ cell tumours using fine needle aspiration cytology. J Clin Pathol 1987, 40, 1324-1333. [PubMed] [Crossref]

  • 11. Kasper D.L., Braunwald E., Fauci A., Hauser S., Longo D., Jameson J.L.: Harrison’s principles of internal medicine. Mc Graw-Hill Professional, New York 2004, pp. 550-553.

  • 12. MacLachlan N.J., Kennedy P.C.: Tumors of the genital system. In: Tumors in Domestic Animals, editor Meuten D.J., Iowa State Press, Iowa 2002, pp. 547-573.

  • 13. Maiolino P., Restucci B., Paparella S., Paciello O., De Vico G.: Correlation of nuclear morphometric features with animal and auman World Health Organization international histological classification of canine spontaneus seminomas. Vet Pathol 2004, 41, 608-611. [Crossref]

  • 14. Malicka E., Piusiński W., Sendecka H., Kielecki W., Osińska B., Lenartowicz-Kubrat Z.: Tumors in dogs in anatomopathological researches since 1985 to 1993. Medycyna Wet 1996, 52, 103-106.

  • 15. Masserdotti C., Bonfanti U., De Lorenzi D., Tranquillo M., Zanetti O.: Cytologic features of testicular tumours in dog. J Vet Med A Physiol Pathol Clin Med 2005, 52, 339-346. [PubMed] [Crossref]

  • 16. Matveev B.P., Gurarii L.L.: Leydig-cell tumors of the testis. Urol Nefrol 1997, 4, 34-36.

  • 17. May K.A., Moll H.D., Duncan R.B., Pleasant R.S., Purswell B.J.: Unilateral Leydig cell tumour resulting in acute colic and scrotal swelling in stallion with descended testes. Equine Vet J 1999, 31, 343-345. [Crossref] [PubMed]

  • 18. Meuten D.J.: Tumors in domestic animals. Iowa State Press, Iowa 2002, pp. 561-573.

  • 19. Michalska Z., Michalski Z.: Prevalence of neoplasms in domestic animals in Wrocław and Lower Silesia during 1976-1995. Medycyna Wet 1997, 53, 263-267.

  • 20. Mischke R., Meurer D., Hoppen H.O., Ueberschar S., Hewicker-Trautwein M.: Blood plasma concetrations of oestradiol-17-β, testosterone and testosterone/oestradiol ratio in dogs with neoplastic and degenerative testicular disease. Res Vet Sci 2002, 73, 267-272.

  • 21. Nielsen S.W., Lein D.H.: Tumours of the testis. Bull World Health Organ 1974, 50, 71-78. [PubMed]

  • 22. Nowak M., Madej J.A.: Manifestation of tumours in domestic animals in Lower Silesia in 2000-2004. Medycyna Wet 2006, 62, 900-904.

  • 23. Nowak M., Madej J.A., Ciaputa R., Poradowski D.: Manifestation of tumours in domestic animals in Lower Silesia in 2005- 2008. Bull Vet Inst Pulawy 2010, 54, 229-236.

  • 24. Peters M.A., de Rooij D.G., Teerds K.J., van de Gaag I., van Sluijs F.J.: Spermatogenesis and testicular tumours in ageing dogs. J Reprod Fertil Suppl 2001, 57, 419-421.

  • 25. Peters M.A., Teerds K.J., van de Gaag I., de Rooij D.G., van Sluijs F.J.: Use of antibodies against LH receptor, 3β-hydroxysteroid dehydrogenase and vimentin to characterize different types of testicular tumour in dogs. Reproduction 2001, 121, 287-296. [Crossref]

  • 26. Restucci B., Maiolino P., Paciello O., Martano M., De Vico G., Papparella S.: Evaluation of angiogenesis in canine seminomas by quantitative immunohistochemistry. J Comp Pathol 2003, 128, 252-259. [Crossref] [PubMed]

  • 27. Reuter V. E.: Origins and molecular biology of testicular germ cell tumors. Mod Pathol 2005, 18, 51-60. [Crossref]

  • 28. Romagnoli S.E.: Canine cryptorchidism. Vet Clin North Am Small Anim Pract 1991, 21, 533-544. [PubMed]

  • 29. Sanpera N., Masot N., Janer M., Romeo C., De Pedro R.: Oestrogen-induced bone marrow aplasia in a dog with Sertoli cell tumour. J Small Anim Pract 2002, 43, 365-369. [Crossref]

  • 30. Sapierzyński R.: Neoplasms of the urinary and genital system in dogs and cats. Part II. Tumors of testes, prostate, penis and prepuce. Życie Wet 2006, 81, 805- 811

  • 31. Scudamore C.L., Meredith A.L.: Sertoli cell tumour in an Amur tiger. J Comp Pathol 2001, 124, 78-82.

  • 32. Takiguchi M., Iida T., Kudo T., Hashimoto A.: Malignant seminoma with systemic metastases in a dog. J Small Anim Pract 2001, 42, 360-362. [Crossref]

  • 33. Taniyama H., Hirayama K., Nakada K., Numagami K., Yaosaka N., Kagawa Y., Izumisawa Y., Nakade T., Tanaka Y., Watanabe G., Taya K.: Immunohistochemical detection of inhibin-α,-β B and -β A chains and 3β-hydroxysteroid dehydrogenase in canine testicular tumors and normal testes. Vet Pathol 2001, 38, 661-666. [Crossref]

  • 34. Thonneau P.F., Candia P., Mieusset R.: Cryptorchidism: incidence, risk factors and potential role of environment. J Androl 2003, 24, 155-162. [PubMed]

  • 35. Weaver D.M., Tyler J.W., Miller M.A., Shore M.D., Cowart R.P.: Bilateral testicular interstitial cell tumour in a aged boar. Vet Rec 2000, 146, 224. [Crossref]

About the article

Published Online: 2013-01-17

Published in Print: 2012-09-01



Citation Information: Bulletin of the Veterinary Institute in Pulawy, ISSN (Print) 0042-4870, DOI: https://doi.org/10.2478/v10213-012-0063-8. Export Citation

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