Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Bulletin of the Veterinary Institute in Pulawy

The Journal of National Veterinary Research Institute in Pulawy

4 Issues per year


IMPACT FACTOR 2016: 0.462

SCImago Journal Rank (SJR) 2016: 0.235
Source Normalized Impact per Paper (SNIP) 2016: 0.364

Open Access
Online
ISSN
2300-3235
See all formats and pricing
Online
Open Access
*Prices in US$ apply to orders placed in the Americas only. Prices in GBP apply to orders placed in Great Britain only. Prices in € represent the retail prices valid in Germany (unless otherwise indicated). Prices are subject to change without notice. Prices do not include postage and handling if applicable. RRP: Recommended Retail Price.
More options …

Effects of Sidr honey on second-intention healing of contaminated full-thickness skin wounds in healthy dogs

Wael M. Hananeh
  • Department of Pathology and Public Health, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
  • Email:
/ Zuhair Bani Ismail
  • Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
 / Musa A. Alshehabat
  • Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
 / Mahmoud Abu Abeeleh
  • Faculty of Medicine, University of Jordan, Amman 11942, Jordan
 / Ja’far Hasan Ali
  • Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan
Published Online: 2015-09-30 | DOI: https://doi.org/10.1515/bvip-2015-0063

Open Access

Download full text pdf

Abstract

The therapeutic effects of Sidr honey on second-intention healing of contaminated full-thickness skin wounds in dogs were investigated. Povidone-iodine was used as a standard treatment and served as a control. Healthy adult (two-to-four-year-old) mongrels, comprising six dogs and two bitches, were divided into four equal groups in order to obtain multi-aged wounds at the end of the study. Four 2cm × 2cm full-thickness skin wounds were created on both sides of the back area of each dog under general anaesthesia adhering to aseptic technique. Contaminated wounds were then divided into two treatment groups: Group 1, Sidr honey treated (right side wounds) and group 2, povidone-iodine treated (left side wounds). All wounds were evaluated grossly daily at the time of treatment application and digitally photographed once every week. Images were analysed using ImageJ software. The parameters of unhealed wound area and length of advancing epithelium were obtained. The epithelialisation areas, percentage of wound area, and wound contraction rate were then calculated. No significant differences were found between the two treatment groups in any of the parameters studied. Overall, both honey treated and iodine treated wounds healed well within the time period of the study (28 d). However, the study showed a beneficial effect of Sidr honey on second-intention healing of full thickness contaminated wounds in healthy dogs and the effect was comparable to that of Povidone iodine.

Keywords: dogs; Sidr honey; povidone-iodine; wounds; wound healing

References

  • 1. Abdel-Wahed R.E., El-Kammar M.H., Korittum A.S., Edrees I.R.: Surgical and histological evaluation of the effectiveness of propolis on wound healing. Alexandria J Vet Sci 2013, 39, 52–63.Google Scholar

  • 2. Adams C.J., Manley-Harris M., Molan P.C.: The origin of methylglyoxal in New Zealand manuka (Leptospermum scoparium) honey. Carbohydr Res 2009, 344, 1050–1053.CrossrefWeb of SciencePubMedGoogle Scholar

  • 3. Al-Waili N., Salom K., Al-Ghamdi A.A.: Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. SciWorld J 2011, 11, 766–787.Google Scholar

  • 4. Alzubier A., Okechukwu P.: Investigation of anti-inflammatory, antipyretic and analgesic effect of Yemeni Sidr Honey. World Acad Sci Engin Technol 2011, 5, 41–46.Google Scholar

  • 5. Bani Ismail Z., Alshehabat M., Hananeh W., Daradka M., Ali J., El-Najjar E.: Recent advances in topical wound healing products with special reference to honey: a review. Res Opin Vet Sci 2015, 5, 76–83.Google Scholar

  • 6. Bischofberger A.S., Dart C.M., Perkins N.R., Kelly A., Jeffcott L., Dart A.J.: The effect of short- and long-term treatment with manuka honey on second intention healing of contaminated and noncontaminated wounds on the distal aspect of the forelimbs in horses. Vet Surg 2013, 42, 154–160.Web of ScienceCrossrefGoogle Scholar

  • 7. Demir A., Şimsek T., Engin M.S., Yildiz L.: The effect of topical honey dressing on wound healing in diabetic mice. Gazi Med J 2007, 18, 110–113.Google Scholar

  • 8. Esmaeelian B., Najafi O., Aldavood S.J., Jalali F.S.S., Farshid A.A., Rahmani S.: Clinical and histopathological evaluations of local honey application in the healing of experimental wounds in dog. J Vet Res 2012, 63, 265–271.Google Scholar

  • 9. Fischbach M.A.: Antibiotics from microbes: converging to kill. Curr Opin Microbiol 2009 12, 520–527.Web of ScienceCrossrefPubMedGoogle Scholar

  • 10. Hammond E.N., Donkor E.S.: Antibacterial effect of manuka honey on Clostridium difficile. BMC Res Notes 2013, 6, 188.CrossrefPubMedGoogle Scholar

  • 11. Hwisa N.T., Katakam P., Chandu B.R., Abadi E.G., Shefha E.M.: Comparative in vivo evaluation of three types of honey on topical wound healing activity in rabbits. J Appl Pharm Sci 2013, 3, 139–143.Google Scholar

  • 12. Jull A.B., Walker N., Deshpande S.: Honey as a topical treatment for wounds. Cochrane Database Syst Re. 2015 Mar 6;3: CD005083. doi: 10.1002/14651858.CD005083.pub4.CrossrefGoogle Scholar

  • 13. Kandemir F.M., Sagliyan A., Ozkaraca M., Gunay C., Han M.C., Benzer F.: Effects of oral administrations of pomegranate seed extract on surgical wound healing in rabbits. Revue Méd Vét 2013, 164, 400–408.Google Scholar

  • 14. Kwakman P.H., Van den Akker J.P., Guclu A., Aslami H., Binnekade J.M., De Boer L., Boszhard L., Paulus F., Middelhoek P., te Velde A.A., Vandenbroucke-Grauls C.M., Schultz M.J., Zaat S.A.: Medical-grade honey kills antibiotic-resistant bacteria in vitro and eradicates skin colonization. Clin Infect Dis 2008, 46, 1677–1682.CrossrefWeb of ScienceGoogle Scholar

  • 15. Marques S.R., Peixoto C.A., Messias J.B., De Albuquerque A.R., Silva Junior V.A.: The effects of topical application of sunflower-seed oil on open wound healing in lambs. Acta Cirurg Brasil 2004, 19, 196–209.CrossrefGoogle Scholar

  • 16. Mavric E., Wittmann S., Barth G., Henle T.: Identification and quantification of methylglyoxal as the dominant antibacterial constituent of manuka (Leptospermum scoparium) honeys from New Zealand. Mol Nutr Food Res 2008, 52, 483–489.Web of SciencePubMedCrossrefGoogle Scholar

  • 17. Molan P.C.: The evidence and the rationale for the use of honey as a wound dressing. Wound Pract Res 2011,19, 204–221.Google Scholar

  • 18. Nisbet H.O., Nisbet C., Yarim M., Guler A., Ozak A.: Effects of three types of honey on cutaneous wound healing. Wounds 2010, 22, 275–283.PubMedGoogle Scholar

  • 19. Overgaauw P.A., Kirpensteijn J.: Honey in treatment of skin wounds. Tijdschr Diergeneeskd 2005, 130, 115–116.PubMedGoogle Scholar

  • 20. Sarabahi S.: Recent advances in topical wound care. Indian J Plast Surg 2012, 45, 379–387.Google Scholar

  • 21. Sazegar G., Seyed Reza A.H., Behravan E.: The effects of supplemental zinc and honey on wound healing in rats. Iran J Basic Med Sci 2011, 14, 391–398.Google Scholar

  • 22. Stojadinovic A., Carlson J.W., Schultz G.S., Davis T.A., Elster E.A.: Topical advances in wound care. Gynecol Oncol 2008, 111, 70–80.CrossrefWeb of ScienceGoogle Scholar

  • 23. Subrahmanyam M.: Topical application of honey for burn wound treatment - an overview. Ann Burns Fire Disasters 2007, 20, 137–139.PubMedGoogle Scholar

  • 24. Sukur S.M., Halim A.S., Singh K.K.: Evaluations of bacterial contaminated full thickness burn wound healing in Sprague Dawley rats treated with Tualang honey. Indian J Plast Surg 2011, 44, 112–117.Google Scholar

  • 25. Tang J., Liu H., Gao C., Mu L., Yang S., Rong M., Zhang Z., Liu J., Ding Q., Lai R.: A small peptide with potential ability to promote wound healing. PLoS One 2014 e92082. doi: 10.1371/journal.pone.0092082.Web of ScienceGoogle Scholar

About the article

Received: 2015-05-03

Accepted: 2015-09-14

Published Online: 2015-09-30

Published in Print: 2015-09-01

Citation Information: Bulletin of the Veterinary Institute in Pulawy, ISSN (Online) 2300-3235, DOI: https://doi.org/10.1515/bvip-2015-0063.

Export Citation

© National Veterinary Research Institute in Pulawy. This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. BY-NC-ND 3.0

Comments (0)

Please log in or register to comment.
Log in