Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 36, Issue 10 (Oct 1998)


Biochemical Evaluation of Oxidative Stress in Propylthiouracil Treated Hyperthyroid Patients. Effects of Vitamin C Supplementation

Arzu Seven / Ertuǧrul Taşan / Figen İnci / Hüsrev Hatemi / Gülden Burçak
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1998.136


In this study the impact of vitamin C supplementation on oxidative damage as assessed by thiobarbituric acid reactive substances and markers of antioxidant status: namely Cu/Zn superoxide dismutase, glutathione peroxidase, glutathione reductase and glutathione were investigated in 24 hyperthyroid patients under propylthiouracil therapy (3×100 mg/day) for five days and in 15 healthy controls. Ascorbic acid (1000 mg/day) was given as a supplement for 1 month to both the patients and controls during the study period. Heparinised blood samples were taken at the beginning and the end of one month ascorbic acid supplementation.

Comparison of the hyperthyroid patients with the controls revealed higher lipid peroxidation (p<0.001), higher Cu/Zn superoxide dismutase activity (p<0.001), higher glutathione level (p<0.001) and lower glutathione reductase activity (p<0.001).

Vitamin C supplementation to hyperthyroid patients caused significant increases in glutathione concentration (p<0.001) and glutathione peroxidase activity (p<0.001), whereas there were significant decreases in glutathione reductase (p<0.001) and Cu/Zn superoxide dismutase activities (p<0.01). Thiobarbituric acid reactive substances and thiobarbituric acid reactive substances/glutathione ratio were significantly decreased (p<0.01).

Vitamin C supplementation to euthyroid controls caused significant increases in glutathione concentration (p<0.001) and glutathione peroxidase and Cu/Zn superoxide dismutase activities (p<0.001), whereas there was a significant decrease in glutathione reductase (p<0.001). The thiobarbituric acid reactive substances/glutathione ratio was significantly decreased (p<0.05).

Our findings reveal the potentiation of antioxidant status and a relief in oxidative stress in both propylthiouracil treated hyperthyroid patients and controls in response to vitamin C supplementation.

About the article

Published Online: 2005-06-01

Published in Print: 1998-10-13

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1998.136.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

O.M. Ahmed, R.G. Ahmed, A.W. El-Gareib, A.M. El-Bakry, and S.M. Abd El-Tawab
International Journal of Developmental Neuroscience, 2012, Volume 30, Number 6, Page 517
Vesna Vrca, Ljiljana Mayer, Franjo Škreb, Dario Rahelić, and Srećko Marušić
Acta Pharmaceutica, 2012, Volume 62, Number 1
P. Tatlı Seven, I. Seven, M. Yılmaz, and Ü.G. Şimşek
Animal Feed Science and Technology, 2008, Volume 146, Number 1-2, Page 137
Osama M. Ahmed, A.W. El-Gareib, A.M. El-bakry, S.M. Abd El-Tawab, and R.G. Ahmed
International Journal of Developmental Neuroscience, 2008, Volume 26, Number 2, Page 147
Hesam A. Seifi, Mehrdad Mohri, Mohammad Delaramy, and Mohammad Harati
Food and Chemical Toxicology, 2010, Volume 48, Number 8-9, Page 2059
Gülnur Andican, Remise Gelişgen, Sabiha Civelek, Arzu Seven, Oktay Seymen, Tuncay Altuğ, Günnur Yiğit, and Gülden Burçak
Journal of Toxicology and Environmental Health, Part A, 2004, Volume 67, Number 5, Page 413
Vesna Bacic Vrca, Franjo Skreb, Ivana Cepelak, Zeljko Romic, and Ljiljana Mayer
Clinica Chimica Acta, 2004, Volume 341, Number 1-2, Page 55
Katarzyna Komosinska-Vassev, Krystyna Olczyk, Eugene J. Kucharz, Czeslaw Marcisz, Katarzyna Winsz-Szczotka, and Anna Kotulska
Clinica Chimica Acta, 2000, Volume 300, Number 1-2, Page 107
Virginia Fernández, Gladys Tapia, Patricia Varela, Pamela Romanque, Denise Cartier-Ugarte, and Luis A. Videla
Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2006, Volume 142, Number 3-4, Page 231
Vesna Bacic-Vrca, Franjo Skreb, Ivana Cepelak, Ljiljana Mayer, Zvonko Kusic, and Blanka Petres
Clinical Chemistry and Laboratory Medicine (CCLM), 2005, Volume 43, Number 4
Ersin Akarsu, Hakan Buyukhatipoglu, Şebnem Aktaran, and Naciye Kurtul
Clinical Endocrinology, 2011, Volume 74, Number 1, Page 118

Comments (0)

Please log in or register to comment.
Log in