Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Specificity of Cardiac Troponins I and T in Renal Disease

Stefan Willging / Frieder Keller / Gerald Steinbach

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 36, Issue 2, Pages 87–92, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.1998.016, June 2005

Publication History

Published Online:


We investigated and compared serum levels of cardiac troponins I(cTnI) and cardiac troponin T (cTnT) in 85 renal patients (chronic renal impairment n = 23, continuous ambulatory peritoneal dialysis n = 20, hemodialysis n = 42). Patients with the following conditions were excluded: myocardial infarction, angina pectoris, liver disease, malignant neoplasms, enforced physical activity, skeletal muscle trauma, myositis, rhabdomyolysis and seizures. Troponin T was measured by the second generation cTnT-ELISA with a cutoff value = 0.1 μg/l. Troponin I was measured by a cTnI immunoassay analyser with a cut-off value = 2.0 μg/l. Additionally, creatine kinase (CK), CK-MB activity, CKMB mass concentration and myoglobin levels were measured. Specificity was determined as the fraction of true-negative cases compared to the total number of false-positive and true-negative cases. Specificity for cTnT was 96 % [78–100] in patients with renal impairment (creatinine > 150 μmol/l), 95 % [75–100] in continuous ambulatory peritoneal dialysis patients, but in hemodialysis patients it was 75 % [53–92] for short-term hemodialysis (< 1 year) and 46 % [24–68] for long-term hemodialysis (> 1 year). There was a weak correlation between cTnT levels and duration of hemodialysis therapy (r = 0.35, n = 34, p < 0.04). Specificity for cTnI in renal impairment patients was 96 % [78–100] and 100 % [84–100] in continuous ambulatory peritoneal dialysis and all hemodialysis patients. None of the studied markers showed higher specificity than cTnI. Only myoglobin was less specific than cTnT in hemodialysis patients. Different clearances of the troponins during dialysis (investigated by pre-hemodialysis and post-hemodialysis levels) cannot explain the discordant results of cTnT and cTnI.

Conclusion: Cardiac troponin I exhibits higher specificity than cardiac troponin T in hemodialysis patients. Uremic myopathy could explain falsely elevated troponin T levels in hemodialysis patients.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Patrick Deléaval, Éric Descombes, Jean-Luc Magnin, Pierre-Yves Martin, and Gilbert Fellay
Néphrologie & Thérapeutique, 2006, Volume 2, Number 2, Page 75
John Sarko and Charles V Pollack
The Journal of Emergency Medicine, 2002, Volume 23, Number 1, Page 57
P.C. Haggart, P.F. Ludman, and A.W. Bradbury
European Journal of Vascular and Endovascular Surgery, 2001, Volume 22, Number 4, Page 301
Josef D. Schwarzmeier, Ahmad Hamwi, Martin Preisel, Christoph Resl, Matthias Preusser, Elfriede Sluga, Ernst Horcher, and Medhat M. Shehata
Human Pathology, 2005, Volume 36, Number 8, Page 917
Dong-Ryeol Ryu, Jung Tak Park, Jung Hwa Chung, Eun Mi Song, Sun Hee Roh, Jeong-Min Lee, Hye Rim An, Mina Yu, Wook Bum Pyun, Gil Ja Shin, Seung-Jung Kim, Duk-Hee Kang, and Kyu Bok Choi
Yonsei Medical Journal, 2011, Volume 52, Number 4, Page 595
Marie C Iliou, Christine Fumeron, Marie O Benoit, Philippe Tuppin, Victorio Menoyo Calonge, Nicole Moatti, Claude Buisson, and Christian Jacquot
American Journal of Kidney Diseases, 2003, Volume 42, Number 3, Page 513
Morie A. Gertz
Leukemia & Lymphoma, 2008, Volume 49, Number 2, Page 194
Jean-Paul Chapelle, Bernard Dubois, Christophe Bovy, Marie-Claire Aldenhoff, Jacques Gielen, and Georges Rorive
Clinical Chemistry and Laboratory Medicine, 2002, Volume 40, Number 3
Nephrology, 2011, Volume 16, Number 3, Page 251
Philip Chen and Milenko Tanasijevic
Seminars in Dialysis, 2001, Volume 13, Number 1, Page 56
I. Buhaescu, H. Izzedine, and A. Covic
International Journal of Clinical Practice, 2005, Volume 59, Number 11, Page 1317
Magdi Hussein, Jaap Mooij, Haysam Roujouleh, and Omer AL Shenawi
Hemodialysis International, 2004, Volume 8, Number 4, Page 332
John F. Heitner, Jeptha P. Curtis, Salman A. Haq, G. Ralph Corey, L. Kristin Newby, and James G. Jollis
Clinical Cardiology, 2005, Volume 28, Number 7, Page 333
Yeshitila Agzew
Clinical Cardiology, 2009, Volume 32, Number 1, Page 15
Tsu-Tuan Wu, Ang Yuan, Chien-Yuan Chen, Wen-Jone Chen, Kwen-Tay Luh, Sow-Hsong Kuo, Fang-Yu Lin, and Pan-Chyr Yang
Shock, 2004, Volume 22, Number 2, Page 95
Jean-Pierre Bertinchant, Anne Polge, Dania Mohty, Richard Nguyen-Ngoc-Lam, Jacques Estorc, Robert Cohendy, Pierre Joubert, Patrice Poupard, Pascale Fabbro-Peray, Fran??oise Monpeyroux, Sophie Poirey, Bertrand Ledermann, Franck Raczka, J??r??me Brunet, Jacques Nigond, and Jean-Emmanuel de la Coussaye
The Journal of Trauma: Injury, Infection, and Critical Care, 2000, Volume 48, Number 5, Page 924
Tsukasa Nakamura, Chifuyu Ushiyama, Hisataka Shoji, and Hikaru Koide
ASAIO Journal, 2002, Volume 48, Number 1, Page 41
Patrick B Deegan, Maureen E Lafferty, Aubrey Blumsohn, Iain S Henderson, and Ellon Mcgregor
Kidney International, 2001, Volume 60, Number 6, Page 2399
Shih-Yuan Hung, Yao-Min Hung, Hua-Chang Fang, Jeng-Hsien Yeh, Gin-Chuan Hung, Cheng-Ju Wu, Kang-Ju Chou, and Hsiao-Min Chung
Blood Purification, 2004, Volume 22, Number 4, Page 338
Nephrology, 2004, Volume 9, Number 2, Page 83
C. Lowbeer, P. Stenvinkel, R. Pecoits-Filho, O. Heimburger, B. Lindholm, S. A. Gustafsson, and A. Seeberger
Journal of Internal Medicine, 2003, Volume 253, Number 2, Page 153

Comments (0)

Please log in or register to comment.