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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
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Volume 36, Issue 4 (Apr 1998)

Issues

The Biochemistry of Gene Therapy for AIDS

Andrea Savarino / Gian Piero Pescarmona / Emilia Turco / Phalguni Gupta
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1998.035

Abstract

Gene therapy has enormous potential and could in the near future involve the clinical biochemist in monitoring its efficacy. The involvement of clinical biochemists in this field could be not only in evaluating the impact of a gene-based strategy on disease progression, but also in measuring the expression of the products of therapeutic genes in treated individuals. Indeed, gene therapy presents new possibilities for the treatment of many diseases and, in particular, merits consideration in the treatment of a fatal disease like AIDS. The aim of this paper is to review the biochemical basis and clinical relevance of the gene therapy approaches directed towards the inhibition of human immunodeficiency virus type-1. We discuss the goals which have been achieved, the problems which have occurred and the efforts that are being made to solve them. In this regard, particular attention is paid to new strategies targeting ‘therapeutic’ enzymes to human immunodeficiency virus type-1 nucleic acids.

About the article

Published Online: 2005-06-01

Published in Print: 1998-04-30


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1998.035.

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[1]
AIDS Patient Care and STDs, 1999, Volume 13, Number 3, Page 207
[2]
Noriyasu Sakai, Koichi Miyake, Noriko Suzuki, and Takashi Shimada
International Journal of Hematology, 2001, Volume 73, Number 4, Page 476
[3]
Andrea Savarino
Expert Opinion on Investigational Drugs, 2006, Volume 15, Number 12, Page 1507
[4]
Andrea Savarino, Gian Piero Pescarmona, and Johan R. Boelaert
Cell Biochemistry and Function, 1999, Volume 17, Number 4, Page 279

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