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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 36, Issue 5


Endemic Nephropathy in Croatia

Dubravka Čvorišćec / Stjepan Čeović / Gordana Boršo / Ana Stavljenić Rukavina
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1998.046


Endemic nephropathy is a chronic renal disease with a high prevalence in a geographically limited area of Croatia. It has also been recorded in some parts of Bosnia, Serbia, Bulgaria and Romania. Despite numerous studies conducted to date, the etiology of this disease has not been clarified. Pathological studies of the kidney in the early stage of endemic nephropathy have shown renal tubules to be the primary sites of the pathologic process with an interstitial tissue reaction, whereas glomerular alterations are of a secondary character. Tubulointerstitial lesions can thus account for the symptoms of the disease, i.e. tubular proteinuria and reduced urine concentration capacity and urine acidification. Also, an increased incidence of malignant tumours of the urinary tract was found in the same geographic area.

About the article

Published Online: 2005-06-01

Published in Print: 1998-05-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 36, Issue 5, Pages 271–277, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1998.046.

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