Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 36, Issue 5


Short-Term Variability in the Concentration of Serum Interleukin-6 and Its Soluble Receptor in Subjectively Healthy Persons

Benoit Dugué / Esa Leppänen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1998.054


The effects of the time of the day and breakfast on the outcome of interleukin-6 and its soluble receptor in serum were studied on 22 subjectively healthy volunteers. We collected blood specimens at 8.00 a.m. after an overnight fast, at 9.30 a.m. after usual breakfast, and at 11.30 a.m. A second group of volunteers (n = 20) was studied during the evening. We observed a significant decrease in the concentration of interleukin-6 after breakfast. This suggests that for assay of this analyte it is preferable to collect specimens after overnight fast. No changes were observed in the concentrations of interleukin-6 soluble receptor. Weak, but significant negative correlations were found between the age of the volunteers and the concentrations of interleukin-6 soluble receptor and between age and the ratio interleukin-6 soluble receptor/interleukin-6. The concentrations of interleukin-6 were positively and significantly correlated with age.

The within-subject variablity was 30 % for interleukin-6,13% for its receptor, and 33.1% for the ratio interleukin-6 soluble receptor/interleukin-6. The between-subject variability was 43.7 % for interleukin-6, 22.2% for its receptor, and 60.2 % for the ratio interleukin-6 soluble receptor/interleukin-6. The indices of individuality (ratio within-subject variability/between-subject variability) were calculated and found to be 0.69, 0.60, and 0.55 for interleukin-6, its soluble receptor, and the ratio interleukin-6 soluble receptor/interleukin-6, respectively. The implications of these indices with the use of health-related reference values is discussed.

About the article

Published Online: 2005-06-01

Published in Print: 1998-05-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 36, Issue 5, Pages 323–325, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1998.054.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Gustav Nilsonne, Mats Lekander, Torbjörn Åkerstedt, John Axelsson, Michael Ingre, and Paul A. Bartell
PLOS ONE, 2016, Volume 11, Number 11, Page e0165799
Agorastos Agorastos, Richard L. Hauger, Donald A. Barkauskas, Tobias Moeller-Bertram, Paul L. Clopton, Uzair Haji, James B. Lohr, Thomas D. Geracioti, Piyush M. Patel, George P. Chrousos, and Dewleen G. Baker
Psychoneuroendocrinology, 2014, Volume 44, Page 71
Ilir Agalliu, Xiaonan Xue, Mary Cushman, Elaine Cornell, Ann W. Hsing, Robert C. Kaplan, Kathryn Anastos, Swapnil Rajpathak, and Gloria Y.F. Ho
Results in Immunology, 2013, Volume 3, Page 79
Andrew J. Fuligni, Eva H. Telzer, Julienne Bower, Michael R. Irwin, Lisa Kiang, and Steve W. Cole
Brain, Behavior, and Immunity, 2009, Volume 23, Number 6, Page 803
Mindi Picotte, Christina Gayer Campbell, and William G. Thorland
Cytokine, 2009, Volume 47, Number 3, Page 162
Yian Gu, Anne Zeleniuch-Jacquotte, Faina Linkov, Karen L. Koenig, Mengling Liu, Lyudmila Velikokhatnaya, Roy E. Shore, Adele Marrangoni, Paolo Toniolo, Anna E. Lokshin, and Alan A. Arslan
Cytokine, 2009, Volume 45, Number 1, Page 44
Gloria Y.F. Ho, Xiao-Nan Xue, Robert D. Burk, Robert C. Kaplan, Elaine Cornell, and Mary Cushman
Cytokine, 2005, Volume 30, Number 1, Page 1
Allison E. Aiello and George A. Kaplan
Biodemography and Social Biology, 2009, Volume 55, Number 2, Page 178
Hermann Wrigge, Jörg Zinserling, Frank Stüber, Tilman von Spiegel, Rudolf Hering, Silke Wetegrove, Andreas Hoeft, and Christian Putensen
Anesthesiology, 2000, Volume 93, Number 6, Page 1413
I. Walshe, P. Robson-Ansley, A. St Clair Gibson, C. Lawrence, K. G. Thompson, and L. Ansley
European Journal of Applied Physiology, 2010, Volume 110, Number 3, Page 619
Benjamin P. Fairfax, Fredrik O. Vannberg, Jayachandran Radhakrishnan, Hakon Hakonarson, Brendan J. Keating, Adrian V.S. Hill, and Julian C. Knight
Human Molecular Genetics, 2010, Volume 19, Number 4, Page 720

Comments (0)

Please log in or register to comment.
Log in