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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 36, Issue 5


Pediatric Reference Intervals for 34 Biochemical Analytes in Urban School Children and Adolescents

Nada Jagarinec / Zlata Flegar-Meštrić / Branka Šurina / Danijela Vrhovski-Hebrang / Vladimira Preden-Kereković
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1998.055


Concentrations of 34 biochemical constituents of sera were determined on 998 randomly selected urban school children and adolescents aged 8–18 years from Zagreb, Croatia. Reference intervals were obtained by using non-parametric methods to estimate 2.5 and 97.5 percentiles of distribution as upper and lower normal reference intervals, according to the IFCC recommendations. These were compared to reference intervals in the healthy adult population, aged 20–30 years from the same geographical area. Serum glucose, potassium, sodium, chloride, magnesium, iron, zinc, total serum proteins and electrophoretic fractions, and amylase, did not show age or sex differences; total serum bilirubin, total calcium, phosphate, high density lipoprotein cholesterol, total iron binding capacity, unsaturated iron binding capacity, copper, aspartate aminotransferase, alkaline phosphatase, cholinesterase, creatine kinase, and lactate dehydrogenase had higher reference intervals than the adult population. Urea, creatinine, urate, alanine aminotransferase, γ-glutamyltransferase, total cholesterol and low density lipoprotein-cholesterol, and triglycerides had lower reference intervals than the adult population.

About the article

Published Online: 2005-06-01

Published in Print: 1998-05-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 36, Issue 5, Pages 327–337, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1998.055.

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