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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 36, Issue 8


Signal Transduction Pathways and Modulation of Gene Activity

Jonathan B. Weitzman / Moshe Yaniv
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1998.091


Research over the last decade has provided us with much information about the mechanisms that integrate signal transduction pathways with specific gene expression programs. We discuss the types of mechanisms used by different pathways to modulate transcription factor activity, citing examples from diverse molecular systems. Careful regulation of these pathways is essential to maintain balanced transcriptional control. Understanding the mechanisms that control gene activity will enable us to intervene therapeutically in diseases associated with deregulated transcriptional activity.

About the article

Published Online: 2005-06-01

Published in Print: 1998-08-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 36, Issue 8, Pages 535–539, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1998.091.

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