Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982

See all formats and pricing
In This Section
Volume 37, Issue 1 (Jan 1999)


Structure, Function and Clinical Significance of Transferrin Receptors

Richard A. Feelders / Ellen P. A. Kuiper-Kramer / Henk G. van Eijk
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1999.001


Iron plays an essential role in a spectrum of metabolic processes. Cellular iron uptake is facilitated by transferrin receptor (TfR)-mediated endocytosis. In recent years more insight has been obtained in TfR physiology and the regulation of cellular iron homeostasis. The synthesis of TfR and the iron storage protein ferritin is regulated reciprocally at the post-transcriptional level according to the cellular iron status. As a result of externalization of TfR during the endocytic cycle, a soluble form of TfR can be detected in serum. The serum TfR (sTfR) level is closely related to erythroid TfR turnover and the prime determinants of the sTfR concentration are cellular iron demands and erythroid proliferation rate. In the absence of a hyperplastic erythropoiesis the sTfR level is a sensitive parameter of early tissue iron deficiency. The entire spectrum of body iron status can be assessed by measurement of serum ferritin and sTfR levels, with ferritin as marker of tissue iron stores and sTfR as index of tissue iron needs. The sTfR may be a promising tool to detect iron deficiency in inflammatory states and in the anaemia of chronic disease as its concentration is, in contrast to ferritin levels, not influenced by the acute phase response. Determination of sTfR levels may also improve assessment of body iron stores during pregnancy and in neonates. Finally, the sTfR may be a useful parameter to monitor erythropoiesis in various clinical settings, for instance in the prediction of the haematological response to erythropoietin treatment. However, standardization of the sTfR assay, with definition of reference and pathological ranges, is necessary for the definitive introduction of the sTfR as major parameter of iron metabolism.

About the article

Published Online: 2005-06-01

Published in Print: 1999-01-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1999.001. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

E. Bárány, I.A. Bergdahl, L.-E. Bratteby, T. Lundh, G. Samuelson, S. Skerfving, and A. Oskarsson
Environmental Research, 2005, Volume 98, Number 2, Page 215
Dietmar Enko, Helga Wagner, Gernot Kriegshäuser, Christine Kimbacher, Robert Stolba, and Gabriele Halwachs-Baumann
Clinical Biochemistry, 2015
Maria Aslam, Shahida Mohsin, Huma Amin, Shabbir Hussain, Nisar Ahmed, and Ayesha Bhalli
Open Journal of Pathology, 2014, Volume 04, Number 02, Page 41
Se Hoon Yoon, Dong Sup Kim, Seung Taek Yu, Sae Ron Shin, and Du Young Choi
Korean Journal of Pediatrics, 2015, Volume 58, Number 1, Page 15
Gerhard Rogler and Stephan Vavricka
Frontiers in Medicine, 2015, Volume 1
Carlos Penha-Gonçalves, Raffaella Gozzelino, and Luciana V. de Moraes
Frontiers in Pharmacology, 2014, Volume 5
Nicole Ebner and Stephan von Haehling
Nutrients, 2013, Volume 5, Number 9, Page 3730
Seppo Parkkila, Onni Niemelä‡,§, Robert S. Britton∥, Robert E. Fleming¶, Abdul Waheed#, Bruce R. Bacon∥, and William S. Sly#
Gastroenterology, 2001, Volume 121, Number 6, Page 1489
Johann Guillemot, Maryssa Canuel, Rachid Essalmani, Annik Prat, and Nabil G. Seidah
Hepatology, 2013, Volume 57, Number 6, Page 2514
Shohreh Khatami, Soghra Rouhi Dehnabeh, Ehsan Mostafavi, Neda Kamalzadeh, Paricheher Yaghmaei, Parinaz Saeedi, Farangis Shariat, Hamideh Bagheriyan, Sirous Zeinali, and Mohammad Taghi Akbari
Hemoglobin, 2013, Volume 37, Number 4, Page 387
P. Guix, M. Parera, J.A. Castro, A. Picornell, M.M. Ramón, and A. Obrador
Gastroenterología y Hepatología, 2003, Volume 26, Number 2, Page 86
Cheng-Yi Chen, Ming-Ming Tsai, Hsiang-Cheng Chi, and Kwang-Huei Lin
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013, Volume 1834, Number 11, Page 2271
Chang Cao and Kimberly O O'Brien
Nutrition Reviews, 2013, Volume 71, Number 1, Page 35
Chang-Geng Yang, Shan-Shan Liu, Bing Sun, Xian-Li Wang, Na Wang, and Song-Lin Chen
Fish & Shellfish Immunology, 2013, Volume 34, Number 3, Page 744
Herculina S. Kruger, Lisanne J. Balk, Michelle Viljoen, and Tammy M. Meyers
Nutrition Research, 2013, Volume 33, Number 1, Page 50
Gabriele Halwachs-Baumann
Wiener Medizinische Wochenschrift, 2012, Volume 162, Number 21-22, Page 478
Marc Sim, Brian Dawson, Grant Landers, Erwin T. Wiegerinck, Dorine W. Swinkels, Mary-Anne Townsend, Debbie Trinder, and Peter Peeling
European Journal of Applied Physiology, 2012, Volume 112, Number 5, Page 1889
C Doyen and MC Revenant
Immuno-analyse & Biologie Spécialisée, 2001, Volume 16, Number 2, Page 71
Donato Dimonte, Maria Pepe, Immacolata Silletti, Luciano Cazzato, and Rosa Fiore
Transfusion and Apheresis Science, 2002, Volume 27, Number 3, Page 211
Juxing Chen and Caroline A. Enns
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012, Volume 1820, Number 3, Page 256
Konstantinos H. Katsanos, Athina Tatsioni, Dimitra Natsi, Dimitrios Sigounas, Dimitrios K. Christodoulou, and Epameinondas V. Tsianos
Journal of Crohn's and Colitis, 2012, Volume 6, Number 1, Page 56
Robert F Labbé and Anjana Dewanji
Clinical Biochemistry, 2004, Volume 37, Number 3, Page 165
Elena Christoforou, Ioannis Papassotiriou, Christophille Skarmoutsou, Stavros Doudounakis, Alexandra Stamoulakatou, and Emmanuel Kanavakis
Journal of Cystic Fibrosis, 2005, Volume 4, Number 3, Page 151
Konstantinos Katsanos, Etienne Cavalier, Marc Ferrante, Valérie Van Hauwaert, Liesbet Henckaerts, Fabian Schnitzler, Afroditi Katsaraki, Maja Noman, Séverine Vermeire, Epameinondas V. Tsianos, Paul Rutgeerts, Jean-Paul Chapelle, and Gert Van Assche
Journal of Crohn's and Colitis, 2007, Volume 1, Number 2, Page 97
R. Abellan, R. Ventura, S. Pichini, M.P. Sarda, A.F. Remacha, J.A. Pascual, I. Palmi, A. Bacosi, R. Pacifici, P. Zuccaro, and J. Segura
Journal of Immunological Methods, 2004, Volume 295, Number 1-2, Page 89
Giorgos L. Chouliaras, Evangelos Premetis, George Tsiftis, Panayiota Drosatou, Ioannis Papassotiriou, Alexandra Stamoulakatou, and Lilia Lycopoulou
Blood Cells, Molecules, and Diseases, 2009, Volume 43, Number 2, Page 163
Mauro Magnani, Dario Corsi, Marzia Bianchi, Mirko Paiardini, Luca Galluzzi, Elisa Gargiullo, Attilio Parisi, and Fabio Pigozzi
Blood Cells, Molecules, and Diseases, 2001, Volume 27, Number 3, Page 559
I. Cavill
Best Practice & Research Clinical Haematology, 2002, Volume 15, Number 2, Page 399
Shang-Ying Tsai, Hsin-Chien Lee, Chiao-Chicy Chen, and Chao-Hsien Lee
Journal of Psychiatric Research, 2003, Volume 37, Number 3, Page 229
Yoshinaga Otaki, Takeshi Nakanishi, Yukiko Hasuike, Rintarou Moriguchi, Masayoshi Nanami, Yasue Hama, Masaaki Izumi, and Yoshihiro Takamitsu
American Journal of Kidney Diseases, 2004, Volume 43, Number 6, Page 1030
Wesley R Harris and Luigi Messori
Coordination Chemistry Reviews, 2002, Volume 228, Number 2, Page 237
Marijn M. Speeckaert, Reinhart Speeckaert, and Joris R. Delanghe
Critical Reviews in Clinical Laboratory Sciences, 2010, Volume 47, Number 5-6, Page 213
Maurizio De Caterina, Ernesto Grimaldi, Giovanni Di Pascale, Giuliana Salerno, Assunta Rosiello, Maria Passaretti, and Francesco Scopacasa
Clinical Chemical Laboratory Medicine, 2005, Volume 43, Number 1
Sandra Margetic, Elizabeta Topic, Andrea Tesija-Kuna, and Ines Vukasovic
Dialysis & Transplantation, 2006, Volume 35, Number 8, Page 520
Bogdan Cylwik, Lech Chrostek, Marta Daniluk, Alicja Koput, and Maciej Szmitkowski
Clinical and Experimental Medicine, 2010, Volume 10, Number 1, Page 73
J. Jason, L. K. Archibald, O. C. Nwanyanwu, M. Bell, R. J. Jensen, E. Gunter, I. Buchanan, J. Larned, P. N. Kazembe, H. Dobbie, and W. R. Jarvis
Clinical & Experimental Immunology, 2001, Volume 126, Number 3, Page 466
International Journal of Laboratory Hematology, 2008, Volume 30, Number 4, Page 306
International Journal of Laboratory Hematology, 2007, Volume 29, Number 5, Page 335
Jong Weon Choi
American Journal of Hematology, 2007, Volume 82, Number 7, Page 685
A. Kogan, V. Filatov, N. Gusev, A. Bereznikova, O. Kolosova, and A. Katrukha
American Journal of Hematology, 2005, Volume 79, Number 4, Page 281
B. Ritchie, Y. McNeil, and D. R. Brewster
Tropical Medicine and International Health, 2004, Volume 9, Number 1, Page 96
Robert A. Bonnah, Martina U. Muckenthaler, Hanqian Carlson, Belen Minana, Caroline A. Enns, Matthias W. Hentze, and Magdalene So
Cellular Microbiology, 2004, Volume 6, Number 5, Page 473
Robert A. Bonnah, Shaun W. Lee, Brandi L. Vasquez, Caroline A. Enns, and Magdalene So
Cellular Microbiology, 2000, Volume 2, Number 3, Page 207
Jong Weon Choi and Soo Hwan Pai
American Journal of Hematology, 2001, Volume 67, Number 2, Page 130

Comments (0)

Please log in or register to comment.
Log in