Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 37, Issue 11-12


Biochemical Factors Influencing Measurement of Cardiac Troponin I in Serum

A. Katrukha / A. Bereznikova / V. Filatov / T. Esakova
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1999.159


Troponin I (cTnI), a sensitive and reliable marker of damaged cardiac tissue, is now widely used in clinics. But the existence of different cTnI assays with a wide variety of cut-off values and discrepancies between the results of measurements of one and the same sample by different assays is puzzling for clinicians. The most urgent issue at the moment is the development of the international standard, which can be used for the calibration of different assays, thus decreasing between assay biases. But another important item, which should be considered by manufacturers, is the standardisation of the epitopes of the antibodies used for the assay development. The importance of such standardisation originates from the complicated biochemical nature of cTnI. Here we briefly try to analyse the main factors that can influence antigen recognition by different antibodies and formulate principles of antibody selection for assay development.

About the article

Published Online: 2005-06-01

Published in Print: 1999-11-18

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 37, Issue 11-12, Pages 1091–1095, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1999.159.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Gabriel Lima-Oliveira, Denis Monneret, Fabrice Guerber, and Gian Cesare Guidi
Critical Reviews in Clinical Laboratory Sciences, 2018, Page 1
Reham F. El-Kased
Journal of Immunoassay and Immunochemistry, 2018, Page 1
Zsuzsanna Szeitner, Anna Doleschall, Marina Varga, Katalin Keltai, Katalin Révész, Róbert E. Gyurcsányi, and Tamás Mészáros
Anal. Methods, 2017
Yasemin U Budak, Kagan Huysal, Mehtap Bulut, and Murat Polat
BMC Clinical Pathology, 2013, Volume 13, Number 1
Robert H Baevsky, Rajesh K Kapur, and Howard A Smithline
BMC Emergency Medicine, 2004, Volume 4, Number 1
Susann Eriksson, Saara Wittfooth, and Kim Pettersson
Critical Reviews in Clinical Laboratory Sciences, 2006, Volume 43, Number 5-6, Page 427
M. Panteghini
Scandinavian Journal of Clinical and Laboratory Investigation, 2001, Volume 61, Number 2, Page 95
Daan van de Kerkhof, Berry Peters, and Volkher Scharnhorst
Scandinavian Journal of Clinical and Laboratory Investigation, 2008, Volume 68, Number 7, Page 513
R. Langhorn and J.L. Willesen
Journal of Veterinary Internal Medicine, 2016, Volume 30, Number 1, Page 36
D. Dorokhin, L.J. van IJzendoorn, A.M. de Jong, L. Nieto, L. Brunsveld, J.G. Orsel, and M.W.J. Prins
New Biotechnology, 2015, Volume 32, Number 5, Page 450
Josef Horak, Can Dincer, Edvina Qelibari, Hüseyin Bakirci, and Gerald Urban
Sensors and Actuators B: Chemical, 2015, Volume 209, Page 478
Randolph L. Winter, Ashley B. Saunders, Sonya G. Gordon, Matthew W. Miller, Katharine T. Sykes, Jan S. Suchodolski, and Jörg M. Steiner
Journal of Veterinary Cardiology, 2014, Volume 16, Number 2, Page 81
Fred S. Apple and Paul O. Collinson
Laboratory Medicine Online, 2014, Volume 4, Number 1, Page 55
Maria Speth, Kerstin Seibold, and Norbert Katz
Clinical Biochemistry, 2002, Volume 35, Number 5, Page 355
Susann Eriksson, Jukka Hellman, and Kim Pettersson
New England Journal of Medicine, 2005, Volume 352, Number 1, Page 98
Mauro Panteghini
Clinica Chimica Acta, 2001, Volume 311, Number 1, Page 19
David Bar-Or, Gregory W. Thomas, Raphael Bar-Or, Leonard Rael, and James V. Winkler
Clinica Chimica Acta, 2005, Volume 362, Number 1-2, Page 65
Charline Wehlou and Joris R Delanghe
Clinica Chimica Acta, 2009, Volume 408, Number 1-2, Page 114
Nishank Jain and S. Susan Hedayati
Seminars in Dialysis, 2011, Volume 24, Number 4, Page 398
Pavai Sthaneshwar, Farhi Ain Jamaluddin, and Yap Sook Fan
Pathology, 2010, Volume 42, Number 5, Page 454
Robert H. Christenson and Daniel Phillips
Pathology, 2011, Volume 43, Number 3, Page 213
A. Katrukha, A. Bereznikova, V. Filatov, and T. Esakova
Clinical Chemistry and Laboratory Medicine, 1999, Volume 37, Number 11-12
Bernd Puschendorf
Clinical Chemistry and Laboratory Medicine, 1999, Volume 37, Number 11-12
Giuseppe Lippi, Giovanni Targher, Massimo Franchini, and Mario Plebani
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 10
Mauro Panteghini, David M. Bunk, Robert H. Christenson, Alexei Katrukha, Robert A. Porter, Heinz Schimmel, Lili Wang, and Jillian R. Tate
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 11
E. P. Altshuler, D. V. Serebryanaya, and A. G. Katrukha
Biochemistry (Moscow), 2010, Volume 75, Number 13, Page 1584
Mauro Panteghini
American Journal of Clinical Pathology, 2002, Volume 118, Number 3, Page 354
Koraljka Mittel, Snjezana Hrabric, and Stefica Dvornik
Point of Care: The Journal of Near-Patient Testing & Technology, 2005, Volume 4, Number 1, Page 27
K. A. Selting, S. E. Lana, G. K. Ogilvie, A. Olmstead, D. L. Mykles, J. Bright, K. L. Richardson, J. A. Walton, E. Monnet, and M. J. Fettman
Veterinary and Comparative Oncology, 2004, Volume 2, Number 3, Page 142

Comments (0)

Please log in or register to comment.
Log in