Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

See all formats and pricing
More options …
Volume 37, Issue 11-12


The Sensitivity of Cardiac Markers: an Evidence-based Approach

Mauro Panteghini / Franca Pagani / Graziella Bonetti
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1999.160


The aim of this study was to determine whether, using an evidence-based approach, the results of the papers found in the literature are valid and sufficiently scientifically rigorous to be used to definitely address the problem of cardiac marker sensitivity in detection of acute myocardial infarction. In particular, the diagnostic sensitivities of myoglobin, creatine kinase (CK)-MB isoenzyme, determined as mass concentration, CK-MB isoforms, and of the two cardiac troponins, troponin I and troponin T, were reviewed using a priori formulated inclusion/exclusion criteria for judging the eligibility of studies to be included in the analysis. A clear final message derived from this systematic analysis is the unacceptably poor diagnostic sensitivity of all evaluated markers at patient admission, with substantial failure rate to rule out myocardial infarction at this time. Myoglobin is at present the most sensitive of the markers studied for excluding early AMI with an optimum timing of sampling at patient presentation and approximately 4 h later. However, this marker cannot be used by itself as a proportion of patients admitted to the hospital with a late infarction could be missed. The early rate of rise of CK-MB mass and troponin T is similar. Maximum sensitivity of these two parameters is achieved by the analysis of a second sample 6 to 12 h after admission. Additional larger studies are needed to address the question which troponin shows earlier release after myocardial damage, and to clarify the role of CK-MB isoforms as a possible early marker of myocardial infarction.

About the article

Published Online: 2005-06-01

Published in Print: 1999-11-18

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 37, Issue 11-12, Pages 1097–1106, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1999.160.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

S Vatansever, V Akkaya, O Erk, Ş Öztürk, MA Karan, N Salmayenli, C Taşçioğlu, and K Güler
Journal of International Medical Research, 2003, Volume 31, Number 2, Page 76
Mauro Panteghini
Chest, 2002, Volume 122, Number 4, Page 1428
Anjith Vupputuri, Saritha Sekhar, Sajitha Krishnan, K. Venugopal, and K.U. Natarajan
Indian Heart Journal, 2015, Volume 67, Number 6, Page 538
Chun Tat Lui, Ho Lam, Koon Ho Cheung, Sze Fai Yip, Kwok Leung Tsui, Chak Wah Kam, Ka Lung Chui, Ping Wa Yam, Beata Morawiec, and Damian Kawecki
The American Journal of Emergency Medicine, 2015, Volume 33, Number 12, Page 1732
Ralph Tölg, Uwe Zeymer, Ralf Birkemeyer, Rainer Wessely, Holger Eggebrecht, Wolfgang Bocksch, Steffen Schneider, Gert Richardt, and Christian Hamm
Clinical Research in Cardiology, 2012, Volume 101, Number 9, Page 727
Kanita Salic and Leon J. De Windt
Current Atherosclerosis Reports, 2012, Volume 14, Number 3, Page 193
Francis M. Fesmire, Robert H. Christenson, Edward P. Fody, and Theodore A. Feintuch
Annals of Emergency Medicine, 2004, Volume 44, Number 1, Page 12
Giorgina Specchia, Caterina Buquicchio, Nicola Pansini, Francesca Di Serio, Vincenzo Liso, Domenico Pastore, Giuseppina Greco, Lucia Ciuffreda, Anna Mestice, and Arcangelo Liso
Journal of Laboratory and Clinical Medicine, 2005, Volume 145, Number 4, Page 212
John T. Nagurney, David F.M. Brown, Claudia Chae, YuChiao Chang, Won G. Chung, Hilarie Cranmer, Li Dan, Jonathan Fisher, Shamai Grossman, Usha Tedrow, Kent Lewandrowski, and Ik-Kyung Jang
The Journal of Emergency Medicine, 2005, Volume 29, Number 4, Page 409
Mauro Panteghini
Jugoslovenska medicinska biohemija, 2004, Volume 23, Number 3, Page 201
Nada Majkic-Singh, Svetlana Ignjatovic, Radmila Kovacevic, Milica Ilic, and Natasa Lalic
Jugoslovenska medicinska biohemija, 2002, Volume 21, Number 1, Page 1
Mauro Panteghini
Clinical Biochemistry, 2000, Volume 33, Number 3, Page 161
Tommaso Trenti
Clinica Chimica Acta, 2003, Volume 333, Number 2, Page 155
Mauro Panteghini, Thomas Linsinger, Alan H.B Wu, Francesco Dati, Fred S Apple, Robert H Christenson, Johannes Mair, and Heinz Schimmel
Clinica Chimica Acta, 2004, Volume 341, Number 1-2, Page 65
Michaela Adamcová, Tomáš Šimůnek, Helena Kaiserová, Olga Popelová, Martin Štěrba, Anna Potáčová, Jaroslava Vávrová, Jana Maláková, and Vladimír Geršl
Toxicology, 2007, Volume 237, Number 1-3, Page 218
Georg Haltern, Sigune Peiniger, Alexander Bufe, Gebhard Reiss, Hartmut Gülker, and Thomas Scheffold
The American Journal of Cardiology, 2010, Volume 105, Number 1, Page 1
Marian Goicoechea, Soledad Garcıéa de Vinuesa, Francisco Gómez-Campderá, Maria José Gutierrez, Paula Blanco, Raquel Amann, and José Luño
American Journal of Kidney Diseases, 2004, Volume 43, Number 5, Page 846
Mauro Panteghini
Clinical Chemistry and Laboratory Medicine (CCLM), 2004, Volume 42, Number 1
Giuseppe Lippi, Federico Schena, Martina Montagnana, Gian Luca Salvagno, and Gian Cesare Guidi
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 9
Giuseppe Lippi, Luca Filippozzi, Martina Montagnana, Gian Luca Salvagno, Massimo Franchini, Gian Cesare Guidi, and Giovanni Targher
Clinical Chemistry and Laboratory Medicine, 2009, Volume 47, Number 3
Shy-Shin Chang, Si-Huei Lee, Jiunn-Yih Wu, Hsiao-Chen Ning, Te-Fa Chiu, Feng-Lin Wang, Jung Hsiang Chen, Chih-Huang Li, Chien-Chang Lee, and Rai-Chi Chan
Journal of Thrombosis and Thrombolysis, 2010, Volume 30, Number 4, Page 472
C. J. McCann, B. M. Glover, I. B.A. Menown, M. J. Moore, J. McEneny, C. G. Owens, B. Smith, P. C. Sharpe, I. S. Young, and J. A. Adgey
European Heart Journal, 2008, Volume 29, Number 23, Page 2843
Massimo Daves, Diego Trevisan, and Roberto Cemin
Journal of Clinical Laboratory Analysis, 2008, Volume 22, Number 6, Page 391
Mauro Panteghini
American Journal of Clinical Pathology, 2002, Volume 118, Number 3, Page 354
Ulla Derhaschnig, Michael M. Hirschl, Paul O. Collinson, David Gaze, Markus Haass, Hugo A. Katus, Frank Chwallek, Margit Mueller-Bardorff, John Kellett, Jordi Ord????ez-Llanos, Miquel Santal??-Bel, Javier Merc??-Munta??ola, Christer Sylv??n, Ilse Schulz, and Rainer Zerback
Point of Care: The Journal of Near-Patient Testing & Technology, 2004, Volume 3, Number 4, Page 162
Sheila A Grant, Mary E Pierce, Darcy J Lichlyter, and David A Grant
Analytical and Bioanalytical Chemistry, 2005, Volume 381, Number 5, Page 1012

Comments (0)

Please log in or register to comment.
Log in