Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 37, Issue 3 (Mar 1999)


Annexin V and Phospholipid Metabolism

Françoise Russo-Marie
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1999.050


Annexins, protein kinases C and cytosolic phospholipase A2 belong to three families of ubiquitous cytoplasmic proteins involved in signal transduction. All annexins share the property of binding to phospholipids in the presence of calcium. Most annexins are substrates for protein kinases C except annexin V, the most ubiquitous and abundant annexin. Protein kinases C (PKC) belong to three distinct groups of kinases, conventional PKCs (cPKCs) that depend on calcium, diacylglycerol and negatively charged phospholipids for their activity, novel PKCs (nPKCs) and atypical PKCs (aPKCs), that do not require calcium for their activity, although they both require negatively charged phospholipids. Cytosolic phospholipase A2 (cPLA2) depends on calcium for its catalytic activity as well as on serine phosphorylation by MAP kinases. We report that annexin V modulates the activity of cPKCs as well as of cPLA2 by interfering with their ability to bind to negatively charged phospholipids and calcium. We propose that annexin V could interfere with the calcium and phospholipid signalling pathway.

About the article

Published Online: 2005-06-01

Published in Print: 1999-03-01

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1999.050.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Molecular Medicine Reports, 2012, Volume 6, Number 6, Page 1249
Gloria Riquelme, Paola Llanos, Erin Tischner, Jessica Neil, and Begoña Campos
Journal of Biological Chemistry, 2004, Volume 279, Number 48, Page 50601
Xiang-Shun Cui, Xing-Hui Shen, Chang-Kwon Lee, Yong-Kook Kang, Teruhiko Wakayama, and Nam-Hyung Kim
Stem Cell Discovery, 2011, Volume 01, Number 01, Page 1
Christopher M.L.S. Bouton, Mir Ahamed Hossain, Laurence P. Frelin, John Laterra, and Jonathan Pevsner
Toxicology and Applied Pharmacology, 2001, Volume 176, Number 1, Page 34
Monira Hoque, Carles Rentero, Rose Cairns, Francesc Tebar, Carlos Enrich, and Thomas Grewal
Cellular Signalling, 2014, Volume 26, Number 6, Page 1213
Joanna Bandorowicz-Pikula, Marcin Wos, and Slawomir Pikula
Molecular Membrane Biology, 2012, Volume 29, Number 7, Page 229
Norman F Neumann and Fernando Galvez
Biotechnology Advances, 2002, Volume 20, Number 5-6, Page 391
Mikkel H. Andersen, Lars Berglund, Torben E. Petersen, and Jan T. Rasmussen
Biochemical and Biophysical Research Communications, 2002, Volume 292, Number 2, Page 550
Bent Brachvogel, Heike Welzel, Helga Moch, Klaus von der Mark, Clementine Hofmann, and Ernst Pöschl
Mechanisms of Development, 2001, Volume 109, Number 2, Page 389
Abdelnaby Khalyfa, Carolyn M Klinge, William C Hall, Xuechun Zhao, Marilyn M Miller, and Eugenia Wang
Experimental Gerontology, 2003, Volume 38, Number 10, Page 1087
Joseph I Kourie and Harold B Wood
Progress in Biophysics and Molecular Biology, 2000, Volume 73, Number 2-4, Page 91
Daniel Martins-de-Souza, Maria Lebar, and Christoph W. Turck
European Archives of Psychiatry and Clinical Neuroscience, 2011, Volume 261, Number 3, Page 217
Joanna Bandorowicz-Pikula, Rene Buchet, and Slawomir Pikula
BioEssays, 2001, Volume 23, Number 2, Page 170

Comments (0)

Please log in or register to comment.
Log in