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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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Volume 37, Issue 3


Apheresis of Plasma Compounds as a Therapeutic Principle in Severe Sepsis and Multiorgan Dysfunction Syndrome

Bernd Stegmayr
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1999.055


During sepsis there is an increase in the plasma content of several compounds, e.g., bacterial toxins, cytokines, cell debris, free hemoglobin and myoglobin. In blood, these compounds activate various cascade systems, which in large amounts or in more vulnerable patients lead to a disseminated intra-vascular coagulopathy (DIC) with multiorgan dysfunction syndrome (MODS) and death, despite conventional intensive care unit therapy. Therapeutic attempts to reverse these conditions have so far been of limited benefit. These effects have mainly been focused on lowering the blood concentration of single substances such as tumor necrosis factor.

By the use of low-and high-flux hemodialysis filters, usually only small amounts of these substances are removed. By the use of plasmapheresis or plasma exchange, the extent of removal is considerably increased. The efficacy varies between the techniques (centrifugation vs. filtration or adsorption) and has also different influences on e.g. the complement system. This report describes these techniques and the therapeutical possibilities given by them. In small trials, blood or plasma exchange has been used as rescue therapy in critically ill patients with a progressive MODS and DIC. A survival of about 80 % of the patients has been reported in these studies and the use of combined therapy will be discussed. Controlled trials are required in this field.

About the article

Published Online: 2005-06-01

Published in Print: 1999-03-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 37, Issue 3, Pages 327–332, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1999.055.

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