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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

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Increased Serum Neopterin Concentrations in Patients with Alzheimer’s Disease

Friedrich Leblhuber / Johannes Walli / Ulrike Demel / Gernot P. Tilz / Bernhard Widner / Dietmar Fuchs

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 37, Issue 4, Pages 429–431, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.1999.070, June 2005

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We measured serum neopterin concentrations in 24 patients with Alzheimer's disease (8 males, 16 females; age: 73.1 ± 6.2 years; free of any infectious process) and fourteen controls of similar age (4 males, 10 females; age: 69.7 ± 8.8 years). Compared to controls, significantly higher concentrations of neopterin (p < 0.01) were found in patients with Alzheimer's disease. Among patients, concentrations of neopterin were higher in those with lower mini-mental-state (p < 0.05), and an invers correlation existed between mini-mental-state and neopterin concentrations. No such association existed with the duration of the disease. There were also significant correlations between neopterin and serum concentrations of immune activation markers such as soluble tumor necrosis factor (TNF) receptor and soluble interleukin-2 receptor (all p < 0.01). Thus, increased concentrations of neopterin in serum of patients with Alzheimer's disease correlate with the severity of dementia. The data imply a chronic state of peripheral immune activation in Alzheimer's disease.

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