Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 37, Issue 7


A Relationship between K-ras Gene Mutations and Some Clinical and Histologic Variables in Patients with Primary Colorectal Carcinoma

Martin Beránek / Jan Bureš / Vladimír Palička / Pavel Jandík / František Langr / Eliška Nejedlá
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.1999.111


Mutations in the Kirsten ras 2 (K-ras) gene were described as early events in the process of colorectal carcinogenesis. The aim of this study was to find a possible relationship between the presence of K-ras mutation in samples of primary colorectal carcinomas and the clinico-pathological data of the investigated patients. Mutation in codon 12 of the K-ras gene was determined in 18 of 53 colorectal carcinomas (34 %) in our group of patients. The presence of K-ras gene mutations was not related to gender, age of subject at diagnosis, staging or cancer location (p > 0.05). Sixteen of the 42 (38 %) moderately differentiated carcinomas, and two of the eight (25 %) well differentiated carcinomas contained K-ras mutation in codon 12, but none of the three poorly differentiated carcinomas contained the mutation. Moderately differentiated tumours contained an aspartate code GAT (in eight cases), a valine code GTT (in six cases), an alanine code GCT (in one case) and a serine code AGT (in one case) in codon 12. Well differentiated tumours contained only the valine code GTT (two cases).

Our results show that the frequency of mutations in the K-ras gene in carcinomas in Central Europe is not different from the frequencies found in other parts of the world. The homogeneous incidence of K-ras mutation does not seem to be related to ethnic factors, dietary habits, or the composition of the diet.

About the article

Published Online: 2005-06-01

Published in Print: 1999-07-01

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 37, Issue 7, Pages 723–727, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.1999.111.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Walid M. Naser, Mohamed A. Shawarby, Dalal M. Al-Tamimi, Arun Seth, Abdulaziz Al-Quorain, Areej M. Al Nemer, Omar M. E. Albagha, and Klaus Brusgaard
PLoS ONE, 2014, Volume 9, Number 11, Page e113350
Yu-Yao Chang, Pei-Ching Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Shone Chen, Jeng-Kai Jiang, Shung-Haur Yang, Wen-Yih Liang, and Shih-Ching Chang
The American Journal of Surgery, 2016, Volume 212, Number 3, Page 537
Jehad Abubaker, Prashant Bavi, Wael Al-Haqawi, Mehar Sultana, Sayer Al-Harbi, Nasser Al-Sanea, Alaa Abduljabbar, Luai H Ashari, Samar Alhomoud, Fouad Al-Dayel, Shahab Uddin, and Khawla S Al-Kuraya
The Journal of Pathology, 2009, Volume 219, Number 4, Page 435
Juan J. Gonz??lez-Aguilera, Soledad Oliart, Mariano Moreno Azcoita, and Antonia M. Fern??ndez-Peralta
American Journal of Clinical Oncology, 2004, Volume 27, Number 1, Page 39
Jen-Kou Lin, Shih-Ching Chang, Huann-Sheng Wang, Shung-Haur Yang, Jeng-Kai Jiang, Wei-Chone Chen, Tzu-Chen Lin, and Anna Fen-Yau Li
Journal of Surgical Oncology, 2006, Volume 94, Number 3, Page 234

Comments (0)

Please log in or register to comment.
Log in