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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

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Volume 38, Issue 11


The Early Fall in Levels of S-100 β in Traumatic Brain Injury

R. Guy M. Jackson / Gurdip S. Samra / Jeremy Radcliffe / G. Heather Clark / Christopher P. Price
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.179


Protein S-100 β has been suggested as a prognostic marker in traumatic brain injury. However, little is known of its behaviour in the immediate post-injury period. With Ethics Committee approval, we recruited 30 patients with a history of head injury presenting to our Accident and Emergency Department. Blood was taken on arrival and at four hours post-injury. Serum S-100 β was estimated using an immunoluminometric assay. Levels of S-100 β were seen to fall rapidly with time. Half-time was distributed non-parametrically with a median of 198 minutes. Using the Mann–Whitney U test we found a statistically significant difference between non-desirable (Glasgow Outcome Score 1–3) and desirable (Glasgow Outcome Score 4–5) outcome on admission (p = 0.0155) but not at four hours (p = 0.1336). Levels of S-100 β fell rapidly after its release following traumatic brain injury. Time after injury is therefore critical in assessing the significance of levels of S-100 β, and sampling should be as early as possible to gain maximum information. If S-100 β is to be assessed as a monitor of ongoing brain injury in the intensive therapy unit sampling must be frequent (e.g. every 4 hours) to be able to detect rises in serum levels before they have decayed to baseline.

About the article

Published Online: 2005-06-01

Published in Print: 2000-11-12

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 11, Pages 1165–1167, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.179.

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