Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982

See all formats and pricing
In This Section
Volume 38, Issue 11 (Nov 2000)


TNF-α and Its Receptors Mediate Graft Rejection and Loss after Liver Transplantation

Almut Grenz / Martin Schenk / Annette Zipfel / Richard Viebahn
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.184


Tumour necrosis factor-α (TNF-α) plays a pivotal role in the immune response and mediates inflammation by its receptors (TNF-RI and TNF-RII), as observed during rejection episodes and impaired graft function after liver transplantation. TNF-α and its receptors were analysed by an ELISA technique in serum samples from 77 consecutive liver transplantations in 63 patients. Samples were collected preoperatively from donors and recipients and then daily in the first two postoperative weeks. Peak levels of TNF-α and its soluble receptors (sTNF-RI and sTNF-RII) in the first and second postoperative week correlated with the extent of reperfusion injury. Impaired graft functions correlated with high sTNF-RI levels preoperatively (> 5 ng/ml, p = 0.01) and in the postoperative period (> 16 ng/ml, p = 0.02). Significantly increased TNF-α (> 25 pg/ml, p = 0.009) and sTNF-RI levels (> 5 ng/ml, p = 0.05) were found in donors of grafts with a high rejection risk. Elevated levels of TNF-α in the postoperative period correlated with an increased rejection risk (> 90 pg/ml, p = 0.02). The activity of the immune system with high concentrations of TNF-α and its receptors both in the recipient and the transplant donor seems to play an essential role in allograft development.

About the article

Published Online: 2005-06-01

Published in Print: 2000-11-12

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.184. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Bruno Salome Morais, Antonio Lucio Teixeira, Jader Freitas Maciel, Angela Aparecida Lima, Izabela Guimaraes Barbosa, and Marcelo Dias Sanches
Transplant Immunology, 2016
Dolores Wolfram, Hubert Hackl, Nadine Eberhart, Theresa Hautz, Ravi Starzl, Nikolaus Thuille, Tanja Wachter, Bettina Zelger, Gerhard Pierer, and Stefan Schneeberger
Vascularized Composite Allotransplantation, 2015, Page 1
D. Fürst, Ch. Zollikofer, H. Schrezenmeier, and J. Mytilineos
Tissue Antigens, 2012, Volume 80, Number 6, Page 502
Julio A. Clavijo-Alvarez, Giselle G. Hamad, Aurèle Taieb, and W.P. Andrew Lee
The Journal of Hand Surgery, 2007, Volume 32, Number 1, Page 104
S. Wei, J. Li, Z. Lian, Y. Chen, Z. Liu, H. You, and J. Gong
Transplantation Proceedings, 2011, Volume 43, Number 5, Page 1971
Michiel C. Warlé, Herold J. Metselaar, Wim C.J. Hop, Inge C. Gyssens, Marcel Kap, Jaap Kwekkeboom, Sjoerd de Rave, Pieter E. Zondervan, Jan N.M. IJzermans, Hugo W. Tilanus, and Gerda J. Bouma
Transplantation, 2003, Volume 75, Number 1, Page 146
Rosa Franco-Gou, Joan Rosell??-Catafau, and Carmen Peralta
Critical Care Medicine, 2006, Volume 34, Number 5, Page 1506
Jun-ichi Suzuki, Sarah E. Cole, Saime Batirel, Hisanori Kosuge, Koichi Shimizu, Mitsuaki Isobe, Peter Libby, and Richard N. Mitchell
American Journal of Transplantation, 2003, Volume 3, Number 8, Page 968

Comments (0)

Please log in or register to comment.
Log in