Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 38, Issue 2

Issues

Sniffing out the Truth: Clinical Diagnosis Using the Electronic Nose

A.K. Pavlou / A.P.F. Turner
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.016

Abstract

Recently the use of smell in clinical diagnosis has been rediscovered due to major advances in odour sensing technology and artificial intelligence (AI). It was well known in the past that a number of infectious or metabolic diseases could liberate specific odours characteristic of the disease stage. Later chromatographic techniques identified an enormous number of volatiles in human clinical specimens that might serve as potential disease markers. “Artificial nose” technology has been employed in several areas of medical diagnosis, including rapid detection of tuberculosis (TB), Helicobacter pylori (HP) and urinary tract infections (UTI). Preliminary results have demonstrated the possibility of identifying and characterising microbial pathogens in clinical specimens. A hybrid intelligent model of four interdependent “tools”, odour generation “kits”, rapid volatile delivery and recovery systems, consistent low drift sensor performance and a hybrid intelligent system of parallel neural networks (NN) and expert systems, have been applied in gastric, pulmonary and urine diagnosis. Initial clinical tests have shown that it may be possible in the near future to use electronic nose technology not only for the rapid detection of diseases such as peptic ulceration, UTI, and TB but also for the continuous dynamic monitoring of disease stages. Major advances in information and gas sensor technology could enhance the diagnostic power of future bio-electronic noses and facilitate global surveillance models of disease control and management.

About the article

Published Online: 2005-06-01

Published in Print: 2000-02-05


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 2, Pages 99–112, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.016.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
I.V. Kruglenko
Semiconductor Physics, Quantum Electronics and Optoelectronics, 2000, Volume 3, Number 4, Page 529
[2]
Mariana Valente Farraia, João Cavaleiro Rufo, Inês Paciência, Francisca Mendes, Luís Delgado, and André Moreira
Porto Biomedical Journal, 2019, Volume 4, Number 4, Page e42
[3]
Seo Yun Park, Yeonhoo Kim, Taehoon Kim, Tae Hoon Eom, Soo Young Kim, and Ho Won Jang
InfoMat, 2019, Volume 1, Number 3, Page 289
[4]
Spiros D. Dimitratos, Allison S. Hommel, Kenneth D. Konrad, Lauren M. Simpson, Jessica J. Wu-Woods, and Daniel F. Woods
Biosensors, 2019, Volume 9, Number 2, Page 62
[5]
M. Haalboom, J.W. Gerritsen, and J. van der Palen
Clinical Microbiology and Infection, 2019
[6]
S. Craig Roberts, L. Morris Gosling, Tim D. Spector, Paul Miller, Dustin J. Penn, and Marion Petrie
Chemical Senses, 2005, Volume 30, Number 8, Page 651
[7]
L. M. Parsons, A. Somoskovi, C. Gutierrez, E. Lee, C. N. Paramasivan, A. Abimiku, S. Spector, G. Roscigno, and J. Nkengasong
Clinical Microbiology Reviews, 2011, Volume 24, Number 2, Page 314
[8]
Martina Kelly
British Journal of General Practice, 2012, Volume 62, Number 600, Page 378
[9]
C. Fischer-Tenhagen, V. Theby, V. Krömker, and W. Heuwieser
Journal of Dairy Science, 2018
[10]
Guido Grilli, Federica Borgonovo, Emanuela Tullo, Ilaria Fontana, Marcella Guarino, and Valentina Ferrante
Biosystems Engineering, 2018
[11]
Krishna C. Persaud
The International Journal of Lower Extremity Wounds, 2005, Volume 4, Number 1, Page 50
[12]
Jan Hendrik Leopold, Roosmarijn TM van Hooijdonk, Peter J Sterk, Ameen Abu-Hanna, Marcus J Schultz, and Lieuwe DJ Bos
BMC Anesthesiology, 2014, Volume 14, Number 1
[13]
Yunkwang Oh, Youngmi Lee, John Heath, and Moonil Kim
IEEE Sensors Journal, 2015, Volume 15, Number 2, Page 637
[14]
Y.S. Cho, S.C. Jung, and S. Oh
Letters in Applied Microbiology, 2015, Volume 60, Number 6, Page 513
[15]
Birgitta Schmekel, Fredrik Winquist, and Anders Vikström
Analytica Chimica Acta, 2014, Volume 840, Page 82
[16]
Alphus D. Wilson and Manuela Baietto
Sensors, 2011, Volume 11, Number 12, Page 1105
[17]
[18]
Marcel Bruins, Jan Willem Gerritsen, Wendy W.J. van de Sande, Alex van Belkum, and Albert Bos
Sensors and Actuators B: Chemical, 2013, Volume 188, Page 1187
[19]
Ulrike Groenhagen, Rita Baumgartner, Aurélien Bailly, Amber Gardiner, Leo Eberl, Stefan Schulz, and Laure Weisskopf
Journal of Chemical Ecology, 2013, Volume 39, Number 7, Page 892
[20]
N. Fens, M. P. van der Schee, P. Brinkman, and P. J. Sterk
Clinical & Experimental Allergy, 2013, Volume 43, Number 7, Page 705
[21]
Laurent Dormont, Jean-Marie Bessière, and Anna Cohuet
Journal of Chemical Ecology, 2013, Volume 39, Number 5, Page 569
[22]
Marcel Bruins, Zeaur Rahim, Albert Bos, Wendy W.J. van de Sande, Hubert Ph. Endtz, and Alex van Belkum
Tuberculosis, 2013, Volume 93, Number 2, Page 232
[23]
Stefan Kippenberger, Jan Havlíček, August Bernd, Diamant Thaçi, Roland Kaufmann, and Markus Meissner
Experimental Dermatology, 2012, Volume 21, Number 9, Page 655
[24]
Larry R. Senesac, Pampa Dutta, Panos G. Datskos, and Michael J. Sepaniak
Analytica Chimica Acta, 2006, Volume 558, Number 1-2, Page 94
[25]
Francesco Spinelli, Antonio Cellini, Joel L. Vanneste, Maria T. Rodriguez-Estrada, Guglielmo Costa, Stefano Savioli, Frans J. M. Harren, and Simona M. Cristescu
Trees, 2012, Volume 26, Number 1, Page 141
[26]
Francisco J. Ibañez and Francis P. Zamborini
Small, 2012, Volume 8, Number 2, Page 174
[28]
[29]
L.T. Tanoue
Yearbook of Pulmonary Disease, 2007, Volume 2007, Page 136
[30]
Limin Zhu, Randal A Seburg, Eric Tsai, Sophie Puech, and Jean-Christophe Mifsud
Journal of Pharmaceutical and Biomedical Analysis, 2004, Volume 34, Number 3, Page 453
[31]
Michael Phillips, Victoria Basa-Dalay, Graham Bothamley, Renee N. Cataneo, Phung Kim Lam, Maria Piedad R. Natividad, Peter Schmitt, and James Wai
Tuberculosis, 2010, Volume 90, Number 2, Page 145
[32]
M. Shirasu and K. Touhara
Journal of Biochemistry, 2011, Volume 150, Number 3, Page 257
[33]
Arūnas Šetkus, Algirdas-Jonas Galdikas, Žilvinas-Andrius Kancleris, Andrius Olekas, Daiva Senulienė, Viktorija Strazdienė, Rytis Rimdeika, and Rokas Bagdonas
Sensors and Actuators B: Chemical, 2006, Volume 115, Number 1, Page 412
[34]
A Gelperin and A T C Johnson
Journal of Breath Research, 2008, Volume 2, Number 3, Page 037015
[35]
S. Sivaramakrishnan, R. Rajamani, C.S. Smith, K.A. McGee, K.R. Mann, and N. Yamashita
Sensors and Actuators B: Chemical, 2008, Volume 132, Number 1, Page 296
[36]
S.F. D'Souza
Biosensors and Bioelectronics, 2001, Volume 16, Number 6, Page 337
[37]
Reinhard Fend, Conrad Bessant, Anthony J Williams, and Anthony C Woodman
Biosensors and Bioelectronics, 2004, Volume 19, Number 12, Page 1581
[38]
Elizabeth L Corbett, Richard W Steketee, Feiko O ter Kuile, Ahmed S Latif, Anatoli Kamali, and Richard J Hayes
The Lancet, 2002, Volume 359, Number 9324, Page 2177
[39]
Nicolas Guernion, Norman M. Ratcliffe, Peter T.N. Spencer-Phillips, and Robin A. Howe
Clinical Chemistry and Laboratory Medicine, 2001, Volume 39, Number 10
[40]
Erica R Thaler and C William Hanson
Expert Review of Medical Devices, 2005, Volume 2, Number 5, Page 559
[41]
Journal of Plant Biotechnology, 2006, Volume 33, Number 3, Page 223
[42]
F. Spinelli, M. Noferini, J. L. Vanneste, and G. Costa
EPPO Bulletin, 2010, Volume 40, Number 1, Page 59
[43]
Liana Iachetta, Lada Malek, and Brian M. Ross
Rapid Communications in Mass Spectrometry, 2010, Volume 24, Number 6, Page 815
[44]
Venkat Bommisetty, Sachin Bhandari, Rojan L. Karmacharya, David A. Rislov, Russell D. Mileham, and David W. Galipeau
IEEE Sensors Journal, 2008, Volume 8, Number 6, Page 983
[45]
Akira Nawashiro, Takako Arai, Hironao Hayashi, Shimpei Fukuda, Hiroshi Tanimoto, Hiroko Kubota, Jun-ichi Koizumi, and Kyuichi Kamoi
Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology), 2005, Volume 47, Number 4, Page 280
[46]
Mark D. Perkins and Jane Cunningham
The Journal of Infectious Diseases, 2007, Volume 196, Number s1, Page S15
[47]
Gary S. Settles
Journal of Fluids Engineering, 2005, Volume 127, Number 2, Page 189

Comments (0)

Please log in or register to comment.
Log in