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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 38, Issue 3


Methods for the Determination of Plasma Total Homocysteine: a Review

Maria Isabel Amores-Sánchez / Miguel Ángel Medina
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.028


Total homocysteine is the sum of all homocysteine species present in plasma. This parameter is valuable for the diagnosis and follow up of cobalamine or folate deficiencies, and it has been accepted as an independent risk factor for premature cardiovascular disease. These reasons justify the introduction of total homocysteine assays in the routine clinical laboratory. In the present review, we discuss the procedures for sample collection, processing and storage, and review the methodologies for measuring total homocysteine. We compare their feasibility as routine methods in the clinical laboratory.

About the article

Published Online: 2005-06-01

Published in Print: 2000-03-25

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 3, Pages 199–204, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.028.

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