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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 38, Issue 3


A New Modular Chemiluminescence Immunoassay Analyser Evaluated

Agostino Ognibene / Christopher J. Drake / Kwan-Yee S. Jeng / Terri E. Pascucci / Stephen Hsu / Francesca Luceri / Gianni Messeri
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.037


Thyrotropin (TSH), free thyroxine (fT4) and testosterone assays have been used as a probe to evaluate the performances of a new modular chemiluminescence (CL) immunoassay analyser, the Abbott Architect™ i2000. The evaluation was run in parallel on other systems that use CL as the detection reaction: DPC Immulite®, Chiron Diagnostics ACS-180 and ACS Centaur (TSH functional sensitivity only). TSH functional sensitivity was 0.0012, 0.009, 0.033 and 0.039 mU/l for the Architect, Immulite, ACS Centaur and ACS-180, respectively. Testosterone functional sensitivity was 0.38, 3.7 and 2.0 nmol/l for Architect, Immulite and ACS-180, respectively. Good correlation was obtained between the ACS-180 and Architect for all assays. The Immulite correlation did not agree well with the Architect or ACS-180 for fT4 and testosterone but was in good agreement for TSH. Regarding fT4 and testosterone, equilibrium dialysis and isotopic dilution gas-chromatography mass-spectrometry (GC-MS) respectively were used as reference methods. For both within- and between-run precision, the Architect showed the best reproducibility for all three analytes (CV < 6%).

About the article

Published Online: 2005-06-01

Published in Print: 2000-03-25

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 3, Pages 251–260, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.037.

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