Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 38, Issue 4

Issues

Measurement of Cholesterol and other Lipoprotein Constituents in the Clinical Laboratory

G. Russel Warnick
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.041

Abstract

Measurements of lipids and lipoproteins in the clinical laboratory have become increasingly important because of their predictive association with cardiovascular diseases, especially coronary artery disease. The US National Institutes of Health-sponsored National Cholesterol Education Program and counterparts in other countries have developed national consensus guidelines for diagnosis and treatment of coronary artery disease which provide risk cut-points and define use of the lipid/lipoprotein analytes in case finding and therapy. Total and low density lipoprotein cholesterol and triglycerides are measured as positive risk factors and high density lipoprotein cholesterol as an inverse risk factor for coronary artery disease. A National Cholesterol Education Program-sponsored expert laboratory panel has developed guidelines for measurements with requisite analytical performance targets for total error and corresponding precision and bias. The US Centers for Disease Control and Prevention have established reference methods for total and high density lipoprotein cholesterol and for triglycerides, with a method for low density lipoprotein cholesterol in development. Standardization programs for research laboratories and a Cholesterol Reference Method Laboratory Network for diagnostic manufacturers and clinical laboratories provide reliable access and documentation of traceability to accepted reference methods.

Methods for the lipid/lipoprotein analytes have improved dramatically in recent years and, coupled with improved chemistry analyzer systems and more attention to standardization by manufacturers, offer considerable improvement in analytical performance. Fully automated homogeneous assays for high density lipoprotein cholesterol and newer similar assays for low-density lipoprotein cholesterol have potential for better precision as well as more convenient and cost-effective measurements. Attention to pre-analytical sources of variation is also important in making reliable classification of patients.

About the article

Published Online: 2005-06-01

Published in Print: 2000-04-30


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 4, Pages 287–300, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.041.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Jan Klouda, Jiří Barek, Karel Nesměrák, and Karolina Schwarzová-Pecková
Critical Reviews in Analytical Chemistry, 2017, Page 1
[2]
Athena Philis-Tsimikas, Addie L. Fortmann, Sapna Dharkar-Surber, Johanna A. Euyoque, Monica Ruiz, James Schultz, and Linda C. Gallo
Translational Behavioral Medicine, 2014, Volume 4, Number 1, Page 18
[3]
Smriti Shivpuri, Matthew A. Allison, Caroline A. Macera, Suzanne Lindsay, and Linda C. Gallo
American Journal of Hypertension, 2013, Volume 26, Number 8, Page 1030
[4]
Rashid Nazir Qureshi, Wim Th. Kok, and Peter J. Schoenmakers
Analytica Chimica Acta, 2009, Volume 654, Number 1, Page 85
[5]
Éric Bruckert
Archives des Maladies du Coeur et des Vaisseaux - Pratique, 2004, Volume 2004, Number 134, Page 36
[6]
E. Bruckert
La Presse Médicale, 2005, Volume 34, Number 3, Page 249
[7]
K. M. Prestwood, C. Unson, M. Kulldorff, and M. Cushman
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2004, Volume 59, Number 8, Page M827
[8]
Anchalee Chittamma, William L. Roberts, Piyamitr Sritara, Sayan Cheepudomwit, Paibul Suriyawongpaisal, and Porntip H. Lolekha
Clinical Biochemistry, 2004, Volume 37, Number 9, Page 745
[9]
Rashid Nazir Qureshi, Erwin Kaal, Hans-Gerd Janssen, Peter J. Schoenmakers, and Wim Th. Kok
Analytica Chimica Acta, 2011, Volume 706, Number 2, Page 361
[10]
S. Shivpuri, L.C. Gallo, P.J. Mills, K.A. Matthews, J.P. Elder, and G.A. Talavera
Brain, Behavior, and Immunity, 2011, Volume 25, Number 6, Page 1256
[11]
Linda C. Gallo, Jessica A. Jiménez, Smriti Shivpuri, Karla Espinosa de los Monteros, and Paul J. Mills
Annals of Behavioral Medicine, 2011, Volume 41, Number 1, Page 21
[12]
Thomas E. Hansen, Kristen Snyder, Erik Messamore, and William F. Hoffman
Laboratory Medicine, 2004, Volume 35, Number 10, Page 625
[13]
Hanna Tolonen, Marco Ferrario, and Kari Kuulasmaa
European Journal of Cardiovascular Prevention & Rehabilitation, 2005, Volume 12, Number 3, Page 257

Comments (0)

Please log in or register to comment.
Log in