Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

Online
ISSN
1437-4331
See all formats and pricing
Volume 38, Issue 4 (Apr 2000)

Issues

Analytical and Clinical Evaluation of Troponin I Determination on Dimension RXL-HM

Gerd Hafner / Dirk Peetz / Francesco Dati / Felix Post / Stefan Blankenberg / Ali A. Peivandi / Bernd Sucké / Hans-Jürgen Rupprecht / Manfred Dahm / Reiner von Kleist / Winfried Prellwitz
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.051

Abstract

The evaluation of cardiac troponin I (cTnI) on the Dimension RxL®-HM analyzer is presented. The one-step enzyme immunoassay is based on two cTnI specific monoclonal antibodies. Performed on a separate module of the analyzer, assay-time is 17 minutes. Using as criterion a between-run impression CV <20% the functional limit of detection was set at 0.1 μg/l. Cutoff level for minor myocardial damage of 0.1 μg/l was found. In Duchenne's dystrophy, patients showed increased cardiac Troponin T (cTnT) but no increased cTnI. In patients with a history of coronary heart disease undergoing chronic hemodialysis, cTnT and cTnI were increased. In different patients with submassive pulmonary embolism, increased cTnI was determined. In coronary artery bypass surgery without perioperative myocardial infarction, patients with extracorporeal circulation showed significantly higher cTnI at 24 h after surgery than those with minimal cardiac surgery. In patients with unstable angina, increased cTnI was found more often than on Stratus analyzer. In conclusion, the new assay is a very sensitive cTnI assay, fast and easy to perform in parallel to enzyme and substrate assays.

About the article

Published Online: 2005-06-01

Published in Print: 2000-04-30


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.051. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
G. Hafner, D. Peetz, H. Erbes, F. P
Scandinavian Journal of Clinical and Laboratory Investigation, 2001, Volume 61, Number 3, Page 227
[2]
Mauro Panteghini
Chest, 2002, Volume 122, Number 4, Page 1428
[3]
G Lefèvre and M Mesguich
Immuno-analyse & Biologie Spécialisée, 2001, Volume 16, Number 6, Page 407
[4]
T.M. Berghaus, T. Haeckel, W. Behr, M. Wehler, W. von Scheidt, and M. Schwaiblmair
Thrombosis Research, 2010, Volume 126, Number 3, Page e201
[5]
Alan H.B Wu, Andrew Smith, Robert H Christenson, MaryAnn M Murakami, and Fred S Apple
Clinica Chimica Acta, 2004, Volume 346, Number 2, Page 211
[6]
Giampaolo Cattozzo, Sergio Finazzi, Sandro Ferrarese, Andrea Sala, and Gian Vico Melzi D'Eril
Clinical Chemistry and Laboratory Medicine, 2001, Volume 39, Number 5
[7]
T. M. Berghaus, C. Thilo, A. Bluethgen, W. von Scheidt, and M. Schwaiblmair
Advances in Therapy, 2010, Volume 27, Number 9, Page 648
[8]
Ulrich Nellessen, Stephan Goder, Robertus Schobre, Miriam Abawi, Hartmut Hecker, and Sigrid Tschöke
Clinical Cardiology, 2006, Volume 29, Number 5, Page 219
[9]
Bertrand Renaud, Patrick Maison, Alfred Ngako, Patrick Cunin, Aline Santin, Jérôme Hervé, Mirna Salloum, Marie-Jeanne Calmettes, Cyril Boraud, Virginie Lemiale, Jean Claude Grégo, Marie Debacker, François Hémery, and Eric Roupie
Academic Emergency Medicine, 2008, Volume 15, Number 3, Page 216

Comments (0)

Please log in or register to comment.
Log in