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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Volume 38, Issue 4 (Apr 2000)


Analytical and Clinical Evaluation of Troponin I Determination on Dimension RXL-HM

Gerd Hafner / Dirk Peetz / Francesco Dati / Felix Post / Stefan Blankenberg / Ali A. Peivandi / Bernd Sucké / Hans-Jürgen Rupprecht / Manfred Dahm / Reiner von Kleist / Winfried Prellwitz
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.051


The evaluation of cardiac troponin I (cTnI) on the Dimension RxL®-HM analyzer is presented. The one-step enzyme immunoassay is based on two cTnI specific monoclonal antibodies. Performed on a separate module of the analyzer, assay-time is 17 minutes. Using as criterion a between-run impression CV <20% the functional limit of detection was set at 0.1 μg/l. Cutoff level for minor myocardial damage of 0.1 μg/l was found. In Duchenne's dystrophy, patients showed increased cardiac Troponin T (cTnT) but no increased cTnI. In patients with a history of coronary heart disease undergoing chronic hemodialysis, cTnT and cTnI were increased. In different patients with submassive pulmonary embolism, increased cTnI was determined. In coronary artery bypass surgery without perioperative myocardial infarction, patients with extracorporeal circulation showed significantly higher cTnI at 24 h after surgery than those with minimal cardiac surgery. In patients with unstable angina, increased cTnI was found more often than on Stratus analyzer. In conclusion, the new assay is a very sensitive cTnI assay, fast and easy to perform in parallel to enzyme and substrate assays.

About the article

Published Online: 2005-06-01

Published in Print: 2000-04-30

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.051. Export Citation

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