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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

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Transformation in the PC-Aided Biochemical Data Analysis

Milan Meloun / Martin Hill / Jiří Militky / Karel Kupka

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 6, Pages 553–559, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2000.081, June 2005

Publication History

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Data transformations enable expression of original data in a new scale, more suitable for data analysis. In computer-aided interactive analysis of biochemical and clinical data an exploratory data analysis often finds that the sample distribution is systematically skewed or does not accept a sample homogeneity. Under such circumstances the original data should be transformed. The power transformation and the Box-Cox transformation improve sample symmetry and also stabilize variance. Both the Hines-Hines selection graph and the plot of logarithm of a maximum likelihood function allow selection of an optimum transformation parameter. The proposed procedure of data transformation in univariate data analysis is illustrated on a determination of 17-hydroxypregnenolone in umbilical blood of a population of newborns. Lower levels of free 5-ene steroids in umbilical blood and elevated levels of 5-ene steroid sulfates indicate a congenital sex-specific placental sulfatase insufficiency. After examination of statistical assumptions by diagnostic plots of an exploratory data analysis the best estimate of a mean value of 17-hydroxypregnenolone is derived.

Citing Articles

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M. Dušková, M. Macourek, M. Šrámková, M. Hill, and Luboslav Stárka
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D. Cibula, J. Skrenkova, M. Hill, and J. J. Stepan
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Martin Hill, Jana Vrbíková, Jana Zárubová, Radmila Kancheva, Marta Velíková, Lyudmila Kancheva, Jana Kubátová, Michaela Dušková, Petr Marusič, Antonín Pařízek, and Luboslav Stárka
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M Hill, A Pařı́zek, J Klak, R Hampl, J Šulcová, H Havlı́ková, O Lapčı́k, M Bičı́ková, T Fait, R Kancheva, D Cibula, V Pouzar, M Meloun, and L Stárka
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Milan Meloun, Martin Hill, Jiři Militky, and Karel Kupka
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