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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

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Operomics: Molecular Analysis of Tissues from DNA to RNA to Protein

Samir M. Hanash

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 38, Issue 9, Pages 805–813, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.116, June 2005

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The identification of coding sequences in a number of species, including human in the near future, has ushered in the post-genome era. In this era, technologies are becoming available that allow the profiling of tissues and cell populations at the genomic, transcriptomic and proteomic levels. The molecular analysis of tissues at all three levels has been referred to as operomics. This review covers some basic technologies for operomics and their application to some lymphoid disorders. It is proposed that no one type of analysis is fully informative and that information that can be derived from the different compartments encompassed in operomics is complementary. Prospects for introducing such profiling technologies into the clinical laboratory will depend on their robustness, their user friendliness and the clinical relevance of the added information they provide, which cannot be captured through other technologies in use in the clinical laboratory.

Citing Articles

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Gary B Smejkal
Expert Review of Proteomics, 2006, Volume 3, Number 4, Page 383
Wendell W. Weber
Paediatric Drugs, 2001, Volume 3, Number 12, Page 863
Samir M. Hanash, Miroslav P. Bobek, David S. Rickman, Tom Williams, Jean Marie Rouillard, Rork Kuick, and Eric Puravs
PROTEOMICS, 2002, Volume 2, Number 1, Page 69
Xianquan Zhan and Dominic M. Desiderio
Mass Spectrometry Reviews, 2005, Volume 24, Number 6, Page 783

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