Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 38, Issue 9


Familial Studies on the Genetics of Cardiovascular Diseases: the Stanislas Cohort

Sophie Visvikis / Catherine Sass / Celine Pallaud / Michael A. Grow / Faiez Zannad / Gérard Siest / Henry A. Erlich / Suzanne Cheng
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.119


In a given individual, the level of cardiovascular risk results from the combination of and interactions between genetic and environmental components. We choose to investigate segregation analysis of intermediate phenotypes in healthy nuclear families, belonging to the Stanislas cohort, a large familial cohort composed of 1006 families, which will be followed for 10 years. We developed a panel of 35 genetic markers including genes involved in lipid metabolism, regulation of blood pressure, thrombosis, platelet function, and endothelial cell adhesion. The allele frequencies of the studied polymorphisms were in agreement with those reported in other Caucasian populations. As an example of segregation analysis, we investigated carotid intima-media thickness (CIMT) variability in a subset sample of the Stanislas cohort. We found that about 30% of CIMT variability was attributable to genetic factors. Associations between CIMT and polymorphisms in apo CIII, cholesteryl ester transfer protein, methylene tetrahydrofolate reductase, and fibrinogen genes were observed and explained about 20% of CIMT variability in men. Furthermore, as another example of association studies, we investigated the relations between E-selectin polymorphisms and blood pressure interindividual variability and longitudinal changes in unrelated adults of this familial population. The E-selectin Phe554 allele was found associated with lower systolic blood pressure and diastolic blood pressure.

About the article

Published Online: 2005-06-01

Published in Print: 2000-09-18

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 9, Pages 827–832, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.119.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Marek H. Dominiczak
Clinical Chemistry and Laboratory Medicine, 2001, Volume 39, Number 10
Marianne Mansour-Chemaly, Nadia Haddy, Gérard Siest, and Sophie Visvikis
Clinical Chemistry and Laboratory Medicine, 2002, Volume 40, Number 11
Gérard Siest
Clinical Chemistry and Laboratory Medicine (CCLM), 2004, Volume 42, Number 7
Eliane Albuisson, Sandy Maumus, Ndeye-Coumba Ndiaye, Bérangère Marie, Nicolas Jay, François Kohler, Gérard Siest, and Sophie Visvikis-Siest
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 1
A W Plat, H E J H Stoffers, O H Klungel, C P van Schayck, P W de Leeuw, F L Soomers, P M Schiffers, A D M Kester, and A A Kroon
Journal of Human Hypertension, 2009, Volume 23, Number 10, Page 659
James F. Meschia and Bradford B. Worrall
Current Neurology and Neuroscience Reports, 2004, Volume 4, Number 5, Page 420
James F. Meschia and Bradford B. Worrall
Current Atherosclerosis Reports, 2003, Volume 5, Number 4, Page 317

Comments (0)

Please log in or register to comment.
Log in