Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 38, Issue 9 (Sep 2000)

Issues

Database Analysis and Gene Discovery in Pharmacogenetics

Philip Board / Natasha Tetlow / Anneke Blackburn / Gareth Chelvanayagam
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.125

Abstract

The global genome research effort has resulted in the creation of extensive DNA and protein sequence databases that are a valuable resource for the identification of new genes and polymorphic variants of enzymes of pharmacogenetic interest. Previously undescribed members of gene families with novel functions and substrate specificities can be identified by database searching and sequence alignment strategies. Since the expressed sequence tag (EST) database contains sequences from many individuals, it can be searched for evidence of polymorphisms that can significantly influence enzyme function. The different approaches to these forms of analysis are reviewed and illustrated with examples from the glutathione transferase gene family.

About the article

Published Online: 2005-06-01

Published in Print: 2000-09-18


Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.125.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Peter I. Mackenzie, Andrew A. Somogyi, and John O. Miners
Pharmacological Research, 2017, Volume 116, Page 7
[2]
Alison J. Shield, Tracy P. Murray, Jean Y. Cappello, Marjorie Coggan, and Philip G. Board
Genomics, 2010, Volume 95, Number 5, Page 299
[3]
Jan Aerts, Yves Wetzels, Nadine Cohen, and Jeroen Aerssens
Human Mutation, 2002, Volume 20, Number 3, Page 162

Comments (0)

Please log in or register to comment.
Log in