Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 38, Issue 9

Issues

Influence of Glutathione S-Transferase M1 and T1 Genotypes on Larynx Cancer Risk among Korean Smokers

Young-Joon Hong / Jin-Kyung Lee / Guk-Haeng Lee / Seok-Il Hong
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2000.134

Abstract

Glutathione S-transferase (GST) isoenzymes are involved in the detoxification of major carcinogens present in tobacco smoke. It is thus conceivable that deficiency in GST activity due to homozygous deletions of the GSTM1 and GSTT1 genes (the null genotypes) may modulate susceptibility to smoking-induced cancers. The influence of the GSTM1 and GSTT1 null genotypes on larynx cancer risk among the Korean population were evaluated using peripheral blood DNA from 82 larynx cancer patients and 63 healthy controls, all of whom were male current smokers. Increased larynx cancer risk was related to the GSTM1 null genotype (odds ratio (OR)=3.53, 95% confidence interval (CI)=1.27−9.83). The OR associated with the GSTT1 null genotype was also increased, but did not reach statistical significance (OR=1.83, 95% CI=0.70−4.79). Individuals lacking both the GSTM1 and GSTT1 genes were at a significantly higher risk for larynx cancer than individuals with both genes present (OR=4.04, 95% CI=1.33−12.30). These data confirm that the GSTM1 null genotype is an important risk modifier for larynx cancer among Korean smokers and combined GSTM1 and GSTT1 null genotypes could be a useful predictor of genetic susceptibility to larynx cancer.

About the article

Published Online: 2005-06-01

Published in Print: 2000-09-18


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 38, Issue 9, Pages 917–919, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2000.134.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
Ö. Öz, N. Aras Ates, L. Tamer, Ö. Yildirim, and U. Adigüzel
European Journal of Ophthalmology, 2006, Volume 16, Number 1, Page 105
[2]
Joice Matos Biselli, Renata Cristina de Angelo Calsaverini Leal, Mariângela Torreglosa Ruiz, Eny Maria Goloni-Bertollo, José Victor Maníglia, Andréa Regina Baptista Rossit, and Érika Cristina Pavarino-Bertelli
Brazilian Journal of Otorhinolaryngology, 2006, Volume 72, Number 5, Page 654
[3]
Murat Ünal, Lülüfer Tamer, Nurcan Aras Ateş, Yücel Akbaş, Yavuz Selim Pata, Yusuf Vayisoğlu, Bahadır Ercan, Kemal Görür, and Uğur Atik
American Journal of Otolaryngology, 2004, Volume 25, Number 5, Page 318
[4]
Xin-Jiang Ying, Cheng-Zhi Xu, Hong-Ming Xu, Zhen-Feng Sun, Jia Zhang, Guo-Liang Wang, and Pin Dong
Gene, 2012, Volume 494, Number 1, Page 11
[5]
Prachi Bajpai, Anil Kumar Tripathi, and Deepa Agrawal
Leukemia Research, 2007, Volume 31, Number 10, Page 1359
[6]
Ana Hatagima, Emmerson C.B. Costa, Christiane F.S. Marques, Rosalina J. Koifman, Paolo Boffetta, and Sergio Koifman
Oral Oncology, 2008, Volume 44, Number 2, Page 200
[7]
Soya Sisy Sam, Vinod Thomas, Kanipakapatanam Sathyanarayana Reddy, Gopalakrishnan Surianarayanan, and Adithan Chandrasekaran
Cancer Epidemiology, 2010, Volume 34, Number 5, Page 626
[9]
Jordi To-Figueras, Manuel Gené, Jesús Gómez-Catalán, Esther Piqué, Natividad Borrego, Manuel Caballero, Francesc Cruellas, Anna Raya, Manuel Dicenta, and Jacint Corbella
Cancer Letters, 2002, Volume 187, Number 1-2, Page 95
[10]
David M. DeMarini
Mutation Research/Reviews in Mutation Research, 2004, Volume 567, Number 2-3, Page 447
[11]
Edyta Reszka, Piotr Czekaj, Jolanta Adamska, and Wojciech Wasowicz
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 8
[12]
Wen-Lei Zhuo, Yan Wang, Xian-Lu Zhuo, Bo Zhu, Yi Zhu, and Zheng-Tang Chen
Journal of Cancer Research and Clinical Oncology, 2009, Volume 135, Number 8, Page 1081
[13]
Nestor R. Rigual, Garth R. Anderson, Thom R. Loree, Sam Wiseman, Sadir Alrawi, and Daniel L. Stoler
The Laryngoscope, 2005, Volume 115, Number 8, Page 1479

Comments (0)

Please log in or register to comment.
Log in