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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
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Volume 39, Issue 10

Issues

Testing the Predictability of the Relative Urinary Supersaturation from the Bonn-Risk-Index for Calcium Oxalate Stone Formation

Norbert Laube / Stefan Hergarten / Albrecht Hesse
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2001.156

Abstract

When introducing a new parameter, it is necessary to compare the power of the new measure with already established ones. For a new method it is quite difficult to compete with established methods which have already ascertained sets of data over many years. A formal comparison of the new parameter with the actual “gold-standard” method can be a useful approach to reduce that problem. It cannot be expected that a new measure would reflect the “gold-standard” method in a simple proportionality. Therefore, it is important to find out the accuracy of the prediction of one parameter from the other, based on simple, e.g. linear, functions.

A number of methods exist to determine the crystallization risk of calcium oxalate salts from urine. The most established method is the calculation of the relative urinary supersaturations with respect to these salts using the EQUIL-program, a program computing the equilibrium concentrations of complexes of primary cations and anions commonly found in urine. The Bonn-Risk-Index (BRI) is a new strategy for the evaluation of the risk of calcium oxalate formation, by performing crystallization experiments on native unprepared urine samples. Although the analytical and computational efforts of both approaches are quite different (relative supersaturation = high, BRI = low), the measurements revealed a considerable and significant linear relationship between the relative urinary calcium oxalate supersaturation, and BRI. We were, therefore, interested in predicting the relative supersaturation from the BRI and in the accuracy of this prediction.

About the article

Published Online: 2005-06-01

Published in Print: 2001-10-23


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 39, Issue 10, Pages 966–969, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.156.

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[1]
NORBERT LAUBE, STEFAN HERGARTEN, BERND HOPPE, MATTHIAS SCHMIDT, and ALBRECHT HESSE
The Journal of Urology, 2004, Volume 172, Number 1, Page 355
[2]
Norbert Laube, Stefan Hergarten, and Albrecht Hesse
Clinical Chemistry and Laboratory Medicine, 2002, Volume 40, Number 6
[3]
Ruth Hönow, Norbert Laube, Anke Schneider, Torsten Keßler, and Albrecht Hesse
British Journal of Nutrition, 2003, Volume 90, Number 02, Page 295
[4]
M. Straub, W. L. Strohmaier, W. Berg, B. Beck, B. Hoppe, N. Laube, S. Lahme, M. Schmidt, A. Hesse, and K. U. Koehrmann
World Journal of Urology, 2005, Volume 23, Number 5, Page 309
[5]
N. Laube and L. Kleinen
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