Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

The Effects of Impaired Trace Element Status on Polymorphonuclear Leukocyte Activation in the Development of Vascular Complications in Type 2 Diabetes Mellitus

S. Caner Karahan / Orhan Değer / Asim Örem / Fahri Uçar / Cihangir Erem / Ahmet Alver / Ekin Önder

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 2, Pages 109–115, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2001.019, June 2005

Publication History

Published Online:


Impaired trace element metabolism may be involved in some of the metabolic dysfunctions, and contribute to the development of vascular complications in diabetic patients. In order to investigate the relationships among diabetes mellitus, trace element status, leukocyte activation and vascular complications, 55 type 2 diabetic patients (34 with vascular complications and 21 without vascular complications) and 50 non-diabetic control subjects were studied. The mean leukocyte count (p<0.001), polymorphonuclear elastase (p<0.001), erythrocyte malondialdehyde (p<0.001), and glycated haemoglobin (p<0.001) levels, and copper/zinc ratio (p<0.001) were found to be higher in diabetic patients than in the control group, but serum zinc levels (p<0.001) and erythrocyte superoxide dismutase activities (p<0.001) were lower, and serum copper levels showed no differences. In patients with vascular complications, the mean leukocyte count (p<0.05), zinc (p<0.05), polymorphonuclear elastase (p<0.05), erythrocyte malondialdehyde (p<0.001) and glycated haemoglobin (p<0.05) levels, and copper/zinc ratio (p<0.001) were significantly different from those patients without complications. Closer correlations between the copper/zinc ratio and polymorphonuclear elastase (r=0.82, p<0.01), erythrocyte malondialdehyde (r=0.46, p<0.05) or erythrocyte superoxide dismutase (r= −0.85, p<0.01) were found in patients with vascular complications compared to those without, and all of those showed significant relationships with poor glycaemic metabolic control. We conclude that zinc deficiency may provoke polymorphonuclear leukocyte activation, and contributes to the development of vascular complications in type 2 diabetic patients. Furthermore, copper/zinc ratio and polymorphonuclear elastase may be used as important markers to evaluate the presence of vascular complications.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Somanatha Jena, Lopamudra Sahu, Dinesh K. Ray, Sagar K. Mishra, and Pradeep K. Chand
Journal of Radioanalytical and Nuclear Chemistry, 2014
Hui Chen, Chao Tan, Zan Lin, and Tong Wu
Computers in Biology and Medicine, 2014, Volume 50, Page 70
Maria Luisa Reina de la Torre, Miguel Navarro-Alarcón, Loreto Martí del Moral, Herminia López-Gª de la Serrana, Magdalena Palomares-Bayo, María Jesús Oliveras López, Rosa María Blanca Herrera, and Ahmad Agil
Biological Trace Element Research, 2014, Volume 158, Number 2, Page 129
Jiancheng Xu, Qi Zhou, Gilbert Liu, Yi Tan, and Lu Cai
Oxidative Medicine and Cellular Longevity, 2013, Volume 2013, Page 1
Fatma Bozkurt, Recep Tekin, Serda Gulsun, Ömer Satıcı, Ozcan Deveci, and Salih Hosoglu
International Journal of Diabetes in Developing Countries, 2013, Volume 33, Number 3, Page 165
Chih-Hung Guo, Pei-Chung Chen, Maw-Sheng Yeh, Der-Yun Hsiung, and Chia-Liang Wang
Clinical Biochemistry, 2011, Volume 44, Number 4, Page 275
Manal Kamal, Mona Salem, Naglaa Kholousi, and Khadega Ashmawy
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2009, Volume 3, Number 4, Page 214
Ye Song, Jianxun Wang, Yan Li, Yibo Du, Gavin E. Arteel, Jack T. Saari, Y. James Kang, and Lu Cai
The American Journal of Pathology, 2005, Volume 167, Number 1, Page 17

Comments (0)

Please log in or register to comment.