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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 39, Issue 2


Regional Reference Values for some Quantities Measured with the ADVIA Centaur Analyser. A Model of Co-operation between the In Vitro Diagnostic Industry and Clinical Laboratories

M. Ferré-Masferrer / X. Fuentes-Arderiu / M. Gomà-Llongueras / A. Alumá-Trullàs / M. Aramendi-Ramos / J. Luis Castaño-Vidriales / M. Esteban-Salan / M. Graells-Ferrer / A. Jiménez-González / C. Jiménez-Lobo / M. López-Esparza / L. Parés-Pollán
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2001.028


This work is a model of co-operation between the in vitro diagnostic industry and clinical laboratories for the production of reference values. Thirteen clinical laboratories having an ADVIA Centaur analyser and representing the majority of the geographical regions of Spain have shared the search for reference individuals and the production of reference values for thyrotropin, free thyroxine, free triiodothyronine, cobalamine and folate concentrations in serum. All the logistic work has been done in co-operation with the Spanish supplier of the ADVIA Centaur analyser. The reference limits produced in the virtual laboratory are derived from the blend of reference values obtained by each laboratory. The multicentre reference limits were estimated according to the recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC).

About the article

Published Online: 2005-06-01

Published in Print: 2001-04-09

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 39, Issue 2, Pages 166–169, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.028.

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