Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

See all formats and pricing


Select Volume and Issue


The Effect of Escherichia Coli-Derived Lipopolysaccharides on Plasma Levels of Malondialdehyde and 3-Nitrotyrosine

Ali Ünlü / Nurten Türközkan / Behzat Cimen / Ufuk Karabicak / Halil Yaman

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 6, Pages 491–493, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.081, June 2005

Publication History

Published Online:


The aim of this study was to determine the effect of Escherichia coli ( E.coli)-derived lipopolysaccharide on rat plasma low density lipoprotein (LDL), malondialdehyde and 3-nitrotyrosine levels (an indicator of protein nitration). Six hours after intraperitoneal administration of E.coli, plasma LDL was measured electrophoretically and malondialdehyde level was measured by spectrophotometric method. Plasma malondialdehyde was significantly (p<0.001) elevated in E.coli-injected rats (4.97 ± 1.33; n=10) in comparison to control animals (1.83 ± 0.5; n=10). In addition, plasma 3-nitrotyrosine level, determined by reversephase HPLC, was also increased in the infected group (2.84 ± 1.17 to 0.22 ± 0.13; n=10). This increase was statistically significant (p<0.001). An increased level of oxidation of lipids and 3-nitrotyrosine was observed as a result of free radical-mediated damage in plasma. In conclusion, asymptomatic infections may increase the risk of atherosclerosis by inducing free radical formation and a consequent increase in the oxidation of LDL.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Mahdi Alamili, Mads Klein, Jens Lykkesfeldt, Jacob Rosenberg, and Ismail Gögenur
Chronobiology International, 2013, Volume 30, Number 9, Page 1174
Dinçer Avlan, Hakan Taşkinlar, Ali Ünlü, Candan Öztürk, Leyla Cinel, Ali Nayci, İsmail Cinel, and Selim Aksöyek
Burns, 2004, Volume 30, Number 8, Page 785
Oguz Koksel, Ismail Cinel, Lulufer Tamer, Leyla Cinel, Ali Ozdulger, Arzu Kanik, Bahadir Ercan, and Ugur Oral
Pulmonary Pharmacology & Therapeutics, 2004, Volume 17, Number 5, Page 263
Natalia Milioti, Alexandra Bermudez-Fajardo, Manuel L. Penichet, and Ernesto Oviedo-Orta
Clinical and Developmental Immunology, 2008, Volume 2008, Page 1
Nehir Sucu, Ali ünlü, Lülüfer Tamer, Barlas Aytacoglu, Bahadir Ercan, Murat Dikmengil, and Ugur Atik
Clinical Chemistry and Laboratory Medicine, 2003, Volume 41, Number 1
Kyung-Ha Yu, Han-Joo Maeng, and Suk-Jae Chung
Journal of Pharmaceutical Investigation, 2010, Volume 40, Number 3, Page 139
Servet Kavak, Lokman Ayaz, Mustafa Emre, Tamer Inal, Lülüfer Tamer, and Ismail Günay
Cell Biochemistry and Function, 2008, Volume 26, Number 4, Page 478
Hüsamettin Erdamar, Nurten Türközkan, Barboros Balabanli, Gonca Ozan, and Filiz Sezen Bircan
Neurochemical Research, 2007, Volume 32, Number 11, Page 1965
Nurten Türközkan, Ilgim Seven, Husamettin Erdamar, and Behzat Çimen
Molecular and Cellular Biochemistry, 2005, Volume 278, Number 1-2, Page 33
Behzat Çimen, Nurten Türközkan, Ali Ünlü, and M. Kemal Erbil
Cell Biochemistry and Function, 2005, Volume 23, Number 4, Page 273
Ilgim Seven, Nurten T�rk�zkan, and Behzat �imen
Molecular and Cellular Biochemistry, 2005, Volume 271, Number 1-2, Page 107

Comments (0)

Please log in or register to comment.