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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


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Increased Serum and Salivary Immunoglobulins against Candida albicans in HIV-Infected Patients with Oral Candidiasis

Christine Drobacheff / Laurence Millon / Michel Monod / Renaud Piarroux / Eric Robinet / René Laurent / Dominique Meillet

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 6, Pages 519–526, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.087, June 2005

Publication History

Published Online:
2005-06-01

Abstract

The aim of this study was to explore anti-Candida albicans systemic and mucosal humoral responses against Candida virulence antigens such as somatic antigen and secreted aspartic proteases (Saps) in HIV-infected patients with oral candidiasis.

Twenty-eight subjects were included in the study: 11 HIV-positive patients without oral candidiasis (group A), 6 HIV-positive patients with oral candidiasis (group B) and 11 HIV-negative healthy controls (group C). Total IgA, IgG and IgM concentrations and antibodies to C. albicans (somatic antigen, Sap1, Sap6) were measured in serum and saliva. We developed a time-resolved immunofluorometric assay with biotin and europium-labeled streptavidin for this purpose.

Salivary total IgA, IgG and IgM concentrations were higher in group B. IgA, IgG and IgM anti-C. albicans antibodies (against somatic antigen, Sap1, Sap6) were higher in saliva and serum from patients from group B compared with patients from group A and controls.

Our results suggest that, in oral candidiasis, HIV-infected patients have a high mucosal response, specifically directed against C. albicans virulence antigens, such as somatic antigen, Sap1 and Sap6.

Citing Articles

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[1]
L Millon, R Piarroux, M Monod, and D Meillet
Médecine et Maladies Infectieuses, 2002, Volume 32, Number 12, Page 696
[2]
Luciana Pomarico, Ivete Pomarico Ribeiro de Souza, Glória Fernanda Barbosa de Araújo Castro, Ricardo Palmier Teles, Ronir Raggio Luiz, and Lucianne Cople Maia
Journal of Dentistry, 2010, Volume 38, Number 1, Page 10
[3]
Luciana Pomarico, Daniella Ferraz Cerqueira, Rosangela Maria de Araujo Soares, Ivete Pomarico Ribeiro de Souza, Gloria Fernanda Barbosa de Araujo Castro, Sigmund Socransky, Anne Haffajee, and Ricardo Palmier Teles
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 2009, Volume 108, Number 2, Page 203
[4]
E. Bard, S. Laibe, S. Clair, S. Biichlé, L. Millon, C. Drobacheff, D. Bettinger, E. Seillès, and D. Meillet
JAIDS Journal of Acquired Immune Deficiency Syndromes, 2002, Volume 31, Number 3, Page 276
[5]
Sophy Laibe, Emmanuel Bard, Sabéha Biichlé, Julien Vielle, Laurence Millon, Christine Drobacheff, Estelle Seilles, and Dominique Meillet
Clinical Chemistry and Laboratory Medicine, 2003, Volume 41, Number 2
[6]
S. Laibe, S. Biichlé, S. Clair, E. Bard, L. Millon, C. Drobacheff, and D. Meillet
Journal de Mycologie Médicale / Journal of Medical Mycology, 2005, Volume 15, Number 2, Page 69
[8]
CARINA SILVA-BOGHOSSIAN, GLÓRIA FERNANDA CASTRO, RICARDO PALMIER TELES, IVETE P. R. DE SOUZA, and ANA PAULA V. COLOMBO
International Journal of Paediatric Dentistry, 2008, Volume 18, Number 3, Page 205
[9]
G. F. Castro, I. P. R. Souza, S. Lopes, P. Stashenko, and R. P. Teles
Oral Microbiology and Immunology, 2004, Volume 19, Number 5, Page 281

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