Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

See all formats and pricing
More options …
Volume 39, Issue 8


Hyperhomocysteinemia as a Risk Factor for Venous Thrombosis

Martin den Heijer / Miranda B.A.J. Keijzer
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2001.117


Classical homocystinuria is associated with arterial vascular diseases and venous thrombosis. In the last decade, several studies have been published indicating that even mild hyperhomocysteinemia is a risk factor for venous thrombosis. The 677C→T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene is an important cause of mild hyperhomocysteinemia, but this polymorphism does not seem to be a risk factor for venous thrombosis. Studies on the interaction between hyperhomocysteinemia and other thrombotic risk factors are conflicting.

Little is known about the pathophysiology of venous thrombosis in hyperhomocysteinemia. Several mechanisms proposed for vascular disease may be applied to venous thrombosis as well. However, up to now there is no satisfying model which might explain a thrombophilic state at plasma homocysteine concentrations in the range of mild hyperhomocysteinemia.

The results of a first clinical intervention study are expected in 2002. As the results are pending, clinicians could perform homocysteine measurements in patients with venous thrombosis if screening for thrombophilia is indicated. Vitamin supplementation could be prescribed if homocysteine levels are elevated. However, the patient should be informed about the uncertainty of the benefits of vitamin supplementation.

About the article

Published Online: 2005-06-01

Published in Print: 2001-08-31

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 39, Issue 8, Pages 710–713, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.117.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Angela M. Devlin, Erland Arning, Teodoro Bottiglieri, Frank M. Faraci, Rima Rozen, and Steven R. Lentz
Blood, 2004, Volume 103, Number 7, Page 2624
Jana Hirmerová
Cor et Vasa, 2013, Volume 55, Number 3, Page e248
Meral Sayin and Bekir Hakan Bakkal
Journal of Cancer Therapy, 2011, Volume 02, Number 05, Page 607
Ibrahim A. Al-Homood
ISRN Rheumatology, 2012, Volume 2012, Page 1
M.E.T. Tesselaar, J. Ouwerkerk, M.A. Nooy, F.R. Rosendaal, and S. Osanto
European Journal of Cancer, 2004, Volume 40, Number 15, Page 2253
W.Gregory Feero
Primary Care: Clinics in Office Practice, 2004, Volume 31, Number 3, Page 685
Wesley E. Stites and Jeffrey W. Froude
Medical Hypotheses, 2007, Volume 68, Number 4, Page 811
Dusko Mirkovic, Nada Majkic-Singh, and Svetlana Ignjatovic
Jugoslovenska medicinska biohemija, 2003, Volume 22, Number 2, Page 127
Mario Nuño-Ayala, Ricardo Carnicer, Mario Alberto Guzmán, Natalia Guillén, María Ángeles Navarro, Carmen Arnal, and Jesús Osada
Clínica e Investigación en Arteriosclerosis, 2010, Volume 22, Number 5, Page 200
Shoshana Revel-Vilk and Gili Kenet
Thrombosis Research, 2006, Volume 118, Number 1, Page 59
Wolfgang Herrmann and Jürgen Geisel
Clinica Chimica Acta, 2002, Volume 326, Number 1-2, Page 47
Jill Vanessa Hunter
Topics in Magnetic Resonance Imaging, 2002, Volume 13, Number 1, Page 23
Marek H. Dominiczak
Clinical Chemistry and Laboratory Medicine, 2001, Volume 39, Number 10
Hayet Fellah, Moncef Feki, Mohamed Hsairi, Haifa Sanhaji, Neziha Kaabachi, Taieb Ben Abdallah, Ziad A. Massy, Hedi Ben Maiz, Bernard Lacour, and Abderraouf Mebazaa
Clinical Chemistry and Laboratory Medicine, 2003, Volume 41, Number 5
Wolfgang Herrmann, Rima Obeid, Heike Schorr, and Jürgen Geisel
Clinical Chemistry and Laboratory Medicine, 2003, Volume 41, Number 11
Pierluigi Toniutto, Carlo Fabris, Edmondo Falleti, Annarosa Cussigh, Elisabetta Fontanini, Davide Bitetto, Ezio Fornasiere, Rosalba Minisini, Tullia De Feo, Francesca Marangoni, and Mario Pirisi
Liver International, 2007, Volume 28, Number 2, Page 257
Mamdouh Ahmed Gabr, Sahar Saad El-Din Bessa, and Enas Arafa El-Zamarani
Hepatology Research, 2010, Volume 40, Number 5, Page 486
Elizabeth Varga
Journal of Genetic Counseling, 2007, Volume 16, Number 3, Page 261
S. Revel-Vilk, A. Chan, M. Bauman, and P. Massicotte
Journal of Thrombosis and Haemostasis, 2003, Volume 1, Number 5, Page 915

Comments (0)

Please log in or register to comment.
Log in