Jump to ContentJump to Main Navigation
Show Summary Details
In This Section

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year


IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982

Online
ISSN
1437-4331
See all formats and pricing
In This Section
Volume 39, Issue 8 (Aug 2001)

Issues

Hyperhomocysteinaemia and Human Reproduction

Willianne L.D.M. Nelen
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2001.126

Abstract

Mild hyperhomocysteinaemia has been identified as a risk factor for arterial disease and venous thrombosis. In 1991, elevated homocysteine concentrations were also suggested to be associated with neural tube defects (NTD). Since then this relationship has been reported frequently, as well as the relationship between NTD and the 677 C→T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene. Meanwhile, disturbances in the homocysteine metabolism have also been reported as a risk factor for early pregnancy loss and for other congenital birth defects. However, besides embryonic or foetal consequences, hyperhomocysteinaemia has also been described as a cause of maternal obstetric complications such as pre-eclampsia. This review is concerned with the role of hyperhomocysteinaemia in human reproduction.

About the article

Published Online: 2005-06-01

Published in Print: 2001-08-31



Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.126. Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
E. Edeler, A. Heubner, R. Kimmig, and A. Köninger
Der Gynäkologe, 2015, Volume 48, Number 2, Page 159
[2]
F. Lombardo, P. Sgrò, L. Gandini, F. Dondero, E. A. Jannini, and A. Lenzi
Journal of Endocrinological Investigation, 2004, Volume 27, Number 9, Page 883
[4]
Eha Nurk, Grethe S. Tell, Helga Refsum, Per M. Ueland, and Stein E. Vollset
The American Journal of Medicine, 2004, Volume 117, Number 1, Page 26
[5]
Salah E. Kassab, Marwan F. Abu-Hijleh, Hani B. Al-Shaikh, and Das S. Nagalla
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2005, Volume 122, Number 2, Page 177
[6]
Joachim Kuhn, Christian Götting, and Knut Kleesiek
Clinical Biochemistry, 2006, Volume 39, Number 2, Page 164
[7]
Patrick J. Stover and Marie A. Caudill
Journal of the American Dietetic Association, 2008, Volume 108, Number 9, Page 1480
[8]
Bernard J. Brabin and Peter M. Johnson
Journal of Reproductive Immunology, 2005, Volume 65, Number 1, Page 1
[9]
Wolfgang Herrmann and Jürgen Geisel
Clinica Chimica Acta, 2002, Volume 326, Number 1-2, Page 47
[11]
Juan Perozo-Romero, Mery Guerra-Velásquez, Eduardo Reyna-Villasmil, Jorly Mejia-Montilla, Nadia Reyna-Villasmil, Duly Torres-Cepeda, Joel Santos-Bolívar, and Helen de Nobrega-Correa
Progresos de Obstetricia y Ginecología, 2011, Volume 54, Number 8, Page 408
[12]
R. DEL GADO, L. PERRONE, D. DEL GAIZO, M. SOMMANTICO, G. POLIDORI, F. CIOCE, P.F. RAMBALDI, and A. SIRIGU
The Journal of Urology, 2003, Volume 170, Number 5, Page 1960
[13]
Ulrich Hübner, Ahmad Alwan, Muhidin Jouma, Mohammad Tabbaa, Heike Schorr, and Wolfgang Herrmann
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 9
[14]
Patrick J. Stover and Cutberto Garza
Nutrition Reviews, 2008, Volume 64, Page S60
[15]
D. Li, N. Karp, Q. Wu, X-L. Wang, S. Melnyk, S. J. James, and R. Rozen
Journal of Inherited Metabolic Disease, 2008, Volume 31, Number 3, Page 403
[16]
Ji Won Suk, Jae-Young Jang, and Jun-Hyeong Cho
Journal of Micromechanics and Microengineering, 2008, Volume 18, Number 5, Page 055024
[17]
Sonja Wintner, Erich Hafner, Felix Stonek, Ingrid Stuempflen, Martin Metzenbauer, and Karl Philipp
Prenatal Diagnosis, 2007, Volume 27, Number 8, Page 704
[18]
S. H. H. M. VERMEULEN, G. M. VAN DER VLEUTEN, J. DE GRAAF, A. R. HERMUS, H. J. BLOM, A. F. H. STALENHOEF, and M. DEN HEIJER
Journal of Thrombosis and Haemostasis, 2006, Volume 4, Number 6, Page 1303
[19]
Martin den Heijer, Sietze Graafsma, Soon Young Lee, Bart van Landeghem, Leo Kluijtmans, Petra Verhoef, Terri H Beaty, and Henk Blom
European Journal of Human Genetics, 2005, Volume 13, Number 6, Page 753

Comments (0)

Please log in or register to comment.
Log in