Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 39, Issue 9 (Sep 2001)


Monotherapy with Metformin: Does It Improve Hypoxia in Type 2 Diabetic Patients?

Vladan Ćosić / Slobodan Antić / Milica Pesić / Olivera Jovanović / Slavica Kundalić / Vidosava B. Djordjević
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2001.135


Metformin reduces blood glucose levels predominantly by inhibiting hepatic gluconeogenesis, although it also may enhance insulin receptor number or activity. The full effects of metformin are still poorly understood. In this study the effects of metformin on plasma xanthine oxidase (XO) activity, thiobarbituric acid-reactive substance (TBARS), lactate and fructosamine concentration as well as erythrocyte antioxidant enzyme activities were investigated in 46 patients with type 2 diabetes mellitus. All parameters were measured simultaneously just before metformin therapy (T0), 1 month (T1) and 2 months (T2) later. Results were compared with placebo and control group. We noted significant decrease in XO activity and in TBARS concentration (p<0.001) during monotherapy with metformin vs. placebo and T0 group. A significant correlation was observed between the activity of XO and the concentration of fructosamine (p<0.001). Erythrocyte glutathione peroxidase showed significantly lower activity in T2 group in comparison with T0 group (p<0.01). It is known that diabetic patients produce more TBARS as a result of enhanced free radical generation the source of which may also be the large amounts of XO produced following the conversion of xanthine dehydrogenase in hypoxic diabetic tissues. Thus, our results indirectly suggest that metformin can reduce toxic tissue damage through the inhibition on XO activity.

About the article

Published Online: 2005-06-01

Published in Print: 2001-09-07

Citation Information: Clinical Chemistry and Laboratory Medicine, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.135.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Takayo Murase, Mai Nampei, Mitsuru Oka, Atsushi Miyachi, and Takashi Nakamura
Journal of Chromatography B, 2016, Volume 1039, Page 51
O.P. Shatova, Eu.V. Butenko, Eu.V. Khomutov, D.S. Kaplun, I.Eu. Sedakov, and I.I. Zinkovych
Biomeditsinskaya Khimiya, 2016, Volume 62, Number 3, Page 302
Seyed Soheil Saeedi Saravi, Amin Hasanvand, Kourosh Shahkarami, and Ahmad Reza Dehpour
Pharmaceutical Biology, 2016, Volume 54, Number 12, Page 2830
Takayo Murase, Mitsuru Oka, Mai Nampei, Atsushi Miyachi, and Takashi Nakamura
Journal of Labelled Compounds and Radiopharmaceuticals, 2016, Volume 59, Number 5, Page 214
Takayo Murase, Mai Nampei, Mitsuru Oka, Naoki Ashizawa, Koji Matsumoto, Atsushi Miyachi, and Takashi Nakamura
Journal of Chromatography B, 2016, Volume 1008, Page 189
Maria Giulia Battelli, Letizia Polito, and Andrea Bolognesi
Atherosclerosis, 2014, Volume 237, Number 2, Page 562
Maria Giulia Battelli, Andrea Bolognesi, and Letizia Polito
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014, Volume 1842, Number 9, Page 1502
D. Bonnefont-Rousselot, B. Raji, S. Walrand, M. Gardès-Albert, D. Jore, A. Legrand, J. Peynet, and M.P. Vasson
Metabolism, 2003, Volume 52, Number 5, Page 586
Nadjat Ouslimani, Jacqueline Peynet, Dominique Bonnefont-Rousselot, Patrice Thérond, Alain Legrand, and Jean-Louis Beaudeux
Metabolism, 2005, Volume 54, Number 6, Page 829
A.B. Motta
The Journal of Steroid Biochemistry and Molecular Biology, 2010, Volume 119, Number 3-5, Page 105
Sheyda Hoseini ., Hadi Esmaily ., Azadeh Mohammadirad ., and Mohammad Abdollahi .
International Journal of Pharmacology, 2006, Volume 2, Number 3, Page 280
Gloria Formoso, Elena A. De Filippis, Noemi Michetti, Patrizia Di Fulvio, Assunta Pandolfi, Tonino Bucciarelli, Giovanni Ciabattoni, Antonio Nicolucci, Giovanni Davì, and Agostino Consoli
Diabetes/Metabolism Research and Reviews, 2008, Volume 24, Number 3, Page 231
Michel K.T. Poon, Po-Yee Chiu, Duncan H.F. Mak, and Kam-Ming Ko
Journal of Pharmacological Sciences, 2003, Volume 93, Number 4, Page 501
P. Gargiulo, D. Caccese, P. Pignatelli, C. Brufani, F. De Vito, R. Marino, R. Lauro, F. Violi, U. Di Mario, and V. Sanguigni
Diabetes/Metabolism Research and Reviews, 2002, Volume 18, Number 2, Page 156

Comments (0)

Please log in or register to comment.
Log in