Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Determination of Serum Cystatin C: Biological Variation and Reference Values

Marie-Madeleine Galteau / Myriam Guyon / René Gueguen / Gérard Siest

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 39, Issue 9, Pages 850–857, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2001.141, June 2005

Publication History

Published Online:


Human cystatin C is a low molecular weight protein which has been proposed as a better marker of glomerular filtration rate than creatinine. To be able to interpret results obtained in different patient populations it is necessary to define cystatin C reference values. We measured serum concentration of cystatin C in 1223 subjects using a particle-enhanced nephelometric assay. Subjects were aged 4 to 79 years and were selected among apparently healthy individuals who came to the Centre for Preventive Medicine in Vandoeuvre-Lès-Nancy, France. We observed a Gaussian distribution of cystatin C concentration in serum. We did not find any effect of age or gender in children, hormonal status in women (puberty, menopause, oral contraceptives or hormone replacement therapy) or alcohol intake. Cystatin C concentration was slightly lower in female than in male adults below the age of 60 years. Cystatin C levels significantly increased above the age of 60 in both males and females, probably due to physiological aging of renal function. No other significant differences were observed between males and females. Using multiple regression analysis, moderate correlations were observed between body mass index and cystatin C, and between smoking and cystatin C, but these were not biologically significant. According to the literature, only methylprednisolone and cyclosporin A increased and decreased cystatin C levels, respectively. The reference values for cystatin C obtained in a carefully selected population were 0.75±0.089 mg/l for children aged 4–19 years, 0.74±0.100 mg/l for males and 0.65±0.085 mg/l for females (aged 20–59 years), and 0.83±0.103 mg/l for older individuals (≥60 years).

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Michele Mussap and Mario Plebani
Critical Reviews in Clinical Laboratory Sciences, 2004, Volume 41, Number 5-6, Page 467
Per A. Sjöström, Ian L. Jones, and Martin A. Tidman
Scandinavian Journal of Clinical and Laboratory Investigation, 2009, Volume 69, Number 1, Page 65
D. Groesbeck, A. Kottgen, R. Parekh, E. Selvin, G. J. Schwartz, J. Coresh, and S. Furth
Clinical Journal of the American Society of Nephrology, 2008, Volume 3, Number 6, Page 1777
Frederique Rodieux, Melanie Wilbaux, Johannes N. van den Anker, and Marc Pfister
Clinical Pharmacokinetics, 2015
Leila C. Volpon, Edward K. Sugo, and Ana P. C. P. Carlotti
Pediatric Critical Care Medicine, 2015, Volume 16, Number 5, Page e125
L.F.E. Ghys, D. Paepe, L. Duchateau, E.R.L. Taffin, S. Marynissen, J. Delanghe, and S. Daminet
The Veterinary Journal, 2015, Volume 204, Number 2, Page 168
Nicolas Maillard, Pierre Delanaye, and Christophe Mariat
Néphrologie & Thérapeutique, 2015, Volume 11, Number 1, Page 54
P. E. Korhonen
International Journal of Clinical Practice, 2015, Volume 69, Number 2, Page 156
Manjula Gowrishankar, Christina VanderPluym, Cheri Robert, Fiona Bamforth, Susan Gilmour, and Ambikaipakan Senthilselvan
Pediatric Transplantation, 2015, Volume 19, Number 1, Page 27
Klaus Meyer and Per Magne Ueland
Analytical Chemistry, 2014, Volume 86, Number 12, Page 5807
L. Ghys, D. Paepe, P. Smets, H. Lefebvre, J. Delanghe, and S. Daminet
Journal of Veterinary Internal Medicine, 2014, Volume 28, Number 4, Page 1152
L. Manetti, E. Pardini, M. Genovesi, A. Campomori, L. Grasso, L. L. Morselli, I. Lupi, G. Pellegrini, L. Bartalena, F. Bogazzi, and E. Martino
Journal of Endocrinological Investigation, 2005, Volume 28, Number 6, Page 346
Johanna Helmersson-Karlqvist, Johan Ärnlöv, Axel C. Carlsson, Johan Härmä, and Anders Larsson
Atherosclerosis, 2014, Volume 234, Number 1, Page 108
João Victor Salgado, Ana Karina França, Nayra Anielly Cabral, Joyce Lages, Valdinar Sousa Ribeiro, Alcione Miranda Santos, and Bernardete Jorge Salgado
Revista da Associação Médica Brasileira, 2013, Volume 59, Number 1, Page 21
A. Softić, L. Begić, A. Halilbašić, T. Vižin, and J. Kos
ISRN Oncology, 2013, Volume 2013, Page 1
João Victor Salgado, Ana Karina França, Nayra Anielly Cabral, Joyce Lages, Valdinar Sousa Ribeiro, Alcione Miranda Santos, and Bernardete Jorge Salgado
Revista da Associação Médica Brasileira (English Edition), 2013, Volume 59, Number 1, Page 21
Pierre Delanaye and Christophe Mariat
Nature Reviews Nephrology, 2013, Volume 9, Number 9, Page 513
N.R. Robles, S. Barroso, and R. Ruiz-Calero
Hipertensión y Riesgo Vascular, 2007, Volume 24, Number 5, Page 201
Thierry Le Bricon
EMC - Biologie Médicale, 2006, Volume 1, Number 1, Page 1
Guido Filler, Abeer Yasin, and Mara Medeiros
Pediatric Nephrology, 2014, Volume 29, Number 2, Page 183
N. Maillard, P. Delanaye, and C. Mariat
EMC - Néphrologie, 2006, Volume 1, Number 1, Page 1
Jan Mares, David Stejskal, Jitka Vavrouskova, Karel Urbanek, Roman Herzig, and Petr Hlustik
Biomedical Papers, 2003, Volume 147, Number 2, Page 177
A. A. Evangelopoulos, N. G. Vallianou, V. Bountziouka, C. Katsagoni, E. Bathrellou, E. D. Vogiatzakis, M. S. Bonou, J. Barbetseas, P. C. Avgerinos, and D. B. Panagiotakos
Internal Medicine Journal, 2012, Volume 42, Number 5, Page 517
P. Monti, G. Benchekroun, D. Berlato, and J. Archer
Journal of Small Animal Practice, 2012, Volume 53, Number 5, Page 254
Dong-Dong Li, Meng-Na Zou, Xin Hu, Mei Zhang, Cheng-Yao Jia, Chuan-Min Tao, Lan-Lan Wang, and Bin-Wu Ying
Journal of Clinical Laboratory Analysis, 2012, Volume 26, Number 2, Page 49
V. Preumont and M. Buysschaert
Médecine des Maladies Métaboliques, 2008, Volume 2, Number 6, Page 612
I. Toft, M. Solbu, J. Kronborg, U. D. Mathisen, B. O. Eriksen, H. Storhaug, T. Melsom, M.-L. Lochen, E. B. Mathiesen, I. Njolstad, T. Wilsgaard, and J. Brox
Nephrology Dialysis Transplantation, 2012, Volume 27, Number 7, Page 2780
Nina Johnston, Tomas Jernberg, Bertil Lindahl, Johan Lindbäck, Mats Stridsberg, Anders Larsson, Per Venge, and Lars Wallentin
Clinical Biochemistry, 2004, Volume 37, Number 3, Page 210
Cahide Anıl Gökkuşu, Tülin Ayse Özden, Hülya Gül, and Alattin Yıldız
Clinical Biochemistry, 2004, Volume 37, Number 2, Page 94
Hafize Uzun, Melek Ozmen Keles, Rezzan Ataman, Seval Aydin, Betül Kalender, Ezel Uslu, Gönül Simsek, Metin Halac, and Safiye Kaya
Clinical Biochemistry, 2005, Volume 38, Number 9, Page 792
Agostino Ognibene, Edoardo Mannucci, Anna Caldini, Alessandro Terreni, Marco Brogi, Gianluca Bardini, Iolanda Sposato, Valentina Mosconi, Benedetta Salvadori, Carlo Maria Rotella, and Gianni Messeri
Clinical Biochemistry, 2006, Volume 39, Number 6, Page 658
Christine A. White, Ayub Akbari, Steve Doucette, Dean Fergusson, Tim Ramsay, Naser Hussain, Laurent Dinh, Guido Filler, Nathalie Lepage, and Greg A. Knoll
American Journal of Kidney Diseases, 2009, Volume 54, Number 5, Page 922
Clara Y. Jones, Camille A. Jones, Ira B. Wilson, Tamsin A. Knox, Andrew S. Levey, Donna Spiegelman, Sherwood L. Gorbach, Frederick Van Lente, and Lesley A. Stevens
American Journal of Kidney Diseases, 2008, Volume 51, Number 6, Page 914
Sanhita Ray, Pavel Lukyanov, and Josiah Ochieng
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2003, Volume 1652, Number 2, Page 91
Celia R. Garlipp, Paula V. Bottini, Rafael R. Queiroz, and Susy H. Afaz
Clinica Chimica Acta, 2008, Volume 393, Number 2, Page 125
Seung-Hwan Lee, Shin-Ae Park, Seung-Hyun Ko, Hyeon-Woo Yim, Yu-Bae Ahn, Kun-Ho Yoon, Bong-Yun Cha, Ho-Young Son, and Hyuk-Sang Kwon
Metabolism, 2010, Volume 59, Number 2, Page 241
Angelos A. Evangelopoulos, Natalia G. Vallianou, Vassiliki P. Bountziouka, Amalia N. Giotopoulou, Maria S. Bonou, John Barbetseas, Peter C. Avgerinos, and Demosthenes B. Panagiotakos
Cardiology Research and Practice, 2011, Volume 2011, Page 1
A.M. Corrao, G. Lisi, G. Di Pasqua, M. Guizzardi, N. Marino, E. Ballone, and P. Lelli Chiesa
The Journal of Urology, 2006, Volume 175, Number 1, Page 303
Anna Köttgen, Elizabeth Selvin, Lesley A. Stevens, Andrew S. Levey, Frederick Van Lente, and Josef Coresh
American Journal of Kidney Diseases, 2008, Volume 51, Number 3, Page 385
James B. Wetmore, Runolfur Palsson, John M. Belmont, Gunnar Sigurdsson, Leifur Franzson, and Olafur S. Indridason
Scandinavian Journal of Urology and Nephrology, 2010, Volume 44, Number 4, Page 242
R. Robles, S. Barroso, and R. Ruiz-Calero
Hipertensión, 2007, Volume 24, Number 5, Page 201
Kiyoshi Ichihara, Kensuke Saito, and Yoshihisa Itoh
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 9
Sean M Bagshaw and Rinaldo Bellomo
Current Opinion in Critical Care, 2010, Volume 16, Number 6, Page 533
Zoran Mijušković, Đorđe Maksić, Rajko Hrvačević, Marina Vučelić, Vesna Subota, Jelica Stojanović, and Janko Pejović
Journal of Medical Biochemistry, 2007, Volume 26, Number 2
J. Mareš, P. Kanovsky, R. Herzig, D. Stejskal, J. Vavrouskova, P. Hlustik, H. Vranova, S. Burval, J. Zapletalova, V. Pidrman, R. Obereigneru, A. Suchy, J. Vesely, J. Podivinsky, and K. Urbanek
Neurological Research, 2009, Volume 31, Number 10, Page 1056
Manuel Fricker, Peter Wiesli, Michael Brändle, Beat Schwegler, and Christoph Schmid
Kidney International, 2003, Volume 63, Number 5, Page 1944
Laurence Viollet, Susan Gailey, David J. Thornton, Neil R. Friedman, Kevin M. Flanigan, John D. Mahan, and Jerry R. Mendell
Muscle & Nerve, 2009, Volume 40, Number 3, Page 438
Trine Borup Andersen, Anni Eskild-Jensen, Jørgen Frøkiær, and Jens Brøchner-Mortensen
Pediatric Nephrology, 2009, Volume 24, Number 5, Page 929
Jan Mares, P. Kanovsky, R. Herzig, D. Stejskal, J. Vavrouskova, P. Hlustik, H. Vranova, S. Burval, J. Zapletalova, V. Pidrman, R. Obereigneru, A. Suchy, J. Vesely, J. Podivinsky, and K. Urbanek
Neurological Sciences, 2009, Volume 30, Number 1, Page 1
A. P. Sharma, A. Kathiravelu, R. Nadarajah, A. Yasin, and G. Filler
Nephrology Dialysis Transplantation, 2008, Volume 24, Number 2, Page 470
Sophie Séronie-Vivien, Pierre Delanaye, Laurence Piéroni, Christophe Mariat, Marc Froissart, and Jean-Paul Cristol
Clinical Chemistry and Laboratory Medicine, 2008, Volume 46, Number 12
Arend Bökenkamp, Stefan Herget-Rosenthal, and Regina Bökenkamp
Pediatric Nephrology, 2006, Volume 21, Number 9, Page 1223
Y-C Ma, L Zuo, J-H Chen, Q Luo, X-Q Yu, Y Li, J-S Xu, S-M Huang, L-N Wang, W Huang, M Wang, G-B Xu, and H-Y Wang
Kidney International, 2007, Volume 72, Number 12, Page 1535
Pierre Delanaye, Eric Nellessen, Etienne Cavalier, Gis??le Depas, St??phanie Grosch, Jean-Olivier Defraigne, Jean-Paul Chapelle, Jean-Marie Krzesinski, and Patrizio Lancellotti
Transplantation, 2007, Volume 83, Number 5, Page 641
Liang-Jen Chuo, Wayne H.H. Sheu, Ming-Chyi Pai, and Yu-Min Kuo
Dementia and Geriatric Cognitive Disorders, 2007, Volume 23, Number 4, Page 251
Fabienne Thomas, Sophie S??ronie-Vivien, Laurence Gladieff, Florence Dalenc, Val??rie Durrand, Laurence Malard, Thierry Lafont, Muriel Poublanc, Roland Bugat, and Etienne Chatelut
Clinical Pharmacokinetics, 2005, Volume 44, Number 12, Page 1305
A. M. Corrao, G. Lisi, G. Di Pasqua, M. Guizzardi, N. Marino, E. Ballone, and P. Lelli Chiesa
The Journal of Urology, 2006, Volume 175, Number 1, Page 303???309
M. Beck, C. Gräf, B. Ellenrieder, A. Bökenkamp, A. Huber, K. Hecher, and P. Bartmann
Pediatric Nephrology, 2005, Volume 20, Number 11, Page 1657
Eric L. Knight, Jacobien C. Verhave, Donna Spiegelman, Hans L. Hillege, Dick De Zeeuw, Gary C. Curhan, and Paul E. De Jong
Kidney International, 2004, Volume 65, Number 4, Page 1416

Comments (0)

Please log in or register to comment.