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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.


IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

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ISSN
1437-4331
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Sickle Cell Disease – Pathophysiology, Clinical and Diagnostic Implications

Alexandra Dorn-Beineke / Thomas Frietsch

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 11, Pages 1075–1084, ISSN (Print) 1434-6621, DOI: 10.1515/cclm.2002.189, June 2005

Publication History

Published Online:
2005-06-01

Abstract

We review the current knowledge of the pathophysiology of sickle cell disease (SCD), the clinical complications and the state of the art in SCD diagnostics. Today, a flexible laboratory concept allows the fast and economic clarification of the patients' sickle cell hemoglobin (HbS) status, e.g. additional compound heterozygosities. In contrast to a well-investigated pathophysiology of the disease, factors influencing the severity of symptoms as well as some laboratory findings in SCD still lack a final explanation. In this review, we focus on red cell lysis resistance as an additional diagnostic tool in SCD. There is a need for further studies regarding lysis resistance in blood samples from patients with HbS.

Citing Articles

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[1]
Hisham Moheeb, Yasser A. Wali, and Mahmoud S. El-Sayed
American Journal of Hematology, 2007, Volume 82, Number 2, Page 91
[2]
D. CARUSO, M. CRESTANI, N. MITRO, L. DA RIVA, R. MOZZI, S. SARPAU, C. MERLOTTI, and C. FRANZINI
Clinical and Laboratory Haematology, 2005, Volume 27, Number 2, Page 111

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