Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter


IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

Online
ISSN
1437-4331
See all formats and pricing
More options …
Volume 40, Issue 11

Issues

Reference Ranges for Serum Concentrations of Lutropin (LH), Follitropin (FSH), Estradiol (E2), Prolactin, Progesterone, Sex Hormone-Binding Globulin (SHBG), Dehydroepiandrosterone Sulfate (DHEAS), Cortisol and Ferritin in Neonates, Children and Young Adults

Martin W. Elmlinger / Werner Kühnel / Michael B. Ranke
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/cclm.2002.202

Abstract

The aim of this study was to establish reference ranges for children (neonates to young adults), for serum lutropin (LH), follitropin (FSH), estradiol (E2), progesterone, prolactin, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), cortisol and ferritin, using the nonisotopic, automated chemiluminescence immunoassay system, Immulite® (DPC).

Serum samples from 762 children (369 female; age 1 day to 19 years) were examined. Of these, 381 were classified as pubertal. Due to non-normal distribution, the 2.5th, 50th and 97.5th percentiles (central 95% interval) were calculated for each group. Statistical differences between the reference ranges were analyzed with respect to age, sex and the stage of sexual maturation.

The median concentrations of E2, prolactin, progesterone, DHEAS, cortisol and ferritin were higher during the first 2 weeks post-partum than thereafter. The largest difference was seen with prolactin, which showed up to 27-fold higher values during this period. In contrast, before the onset of puberty, hardly any sex difference was observed and all analyte concentrations remained relatively constant, apart from SHBG which increased steadily after the neonatal period.

The increase of gonadal activity in females with the onset of sexual maturation included an increase in LH and FSH, which was accompanied by a strong increase in E2, progesterone and prolactin. Cortisol increased to a lesser extent during puberty. In males, the increase in the median concentrations of the hormones was smaller, except for DHEAS. The concentration of ferritin was high in the neonatal period but did not change during sexual maturation.

Our findings agree with earlier studies. The calculated reference intervals can be used to assess the development of children, particularly for measurements performed by the Immulite and Immulite 2000 chemiluminescence assay systems.

About the article

Published Online: 2005-06-01

Published in Print: 2002-12-02


Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 40, Issue 11, Pages 1151–1160, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/cclm.2002.202.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

[1]
K. Jean Forney, Pamela K. Keel, Shannon O'Connor, Cheryl Sisk, S. Alexandra Burt, and Kelly L. Klump
Journal of Psychiatric Research, 2018
[2]
Molly O Regelmann, Manmohan K Kamboj, Bradley S Miller, Jon M Nakamoto, Kyriakie Sarafoglou, Sejal Shah, Takara L Stanley, and Rose Marino
The Journal of Clinical Endocrinology & Metabolism, 2018, Volume 103, Number 11, Page 4324
[3]
Sílvia Xargay-Torrent, Gemma Carreras-Badosa, Sara Borrat-Padrosa, Anna Prats-Puig, Pilar Soriano, Elena Álvarez-Castaño, Mª Jose Ferri, Francis De Zegher, Lourdes Ibáñez, Abel López-Bermejo, Judit Bassols, and Zhong-Cheng Luo
PLOS ONE, 2018, Volume 13, Number 10, Page e0205592
[4]
Paul M. Macey, Janani P. Prasad, Jennifer A. Ogren, Ammar S. Moiyadi, Ravi S. Aysola, Rajesh Kumar, Frisca L. Yan-Go, Mary A. Woo, M. Albert Thomas, and Ronald M. Harper
NeuroImage: Clinical, 2018
[5]
Yaowaluck Hongkaew, Sadeep Medhasi, Ekawat Pasomsub, Nattawat Ngamsamut, Apichaya Puangpetch, Natchaya Vanwong, Monpat Chamnanphon, Penkhae Limsila, Chuthamanee Suthisisang, Bob Wilffert, and Chonlaphat Sukasem
The Pharmacogenomics Journal, 2018
[8]
Yoshiaki Yamanaka, Kunitaka Menuki, Takafumi Tajima, Yasuaki Okada, Kenji Kosugi, Yukichi Zenke, and Akinori Sakai
Journal of Cellular Physiology, 2018
[10]
Flaminia Fanelli, Federico Baronio, Rita Ortolano, Marco Mezzullo, Alessandra Cassio, Uberto Pagotto, and Antonio Balsamo
Sexual Development, 2018
[11]
Seung Hee Cho, Yohan Choi, Sean Hyungwoo Kim, Sang Jin Kim, and Jongwha Chang
Molecular & Cellular Toxicology, 2017, Volume 13, Number 4, Page 351
[12]
Valeria Calcaterra, Hellas Cena, Annalisa de Silvestri, Riccardo Albertini, Mara De Amici, Mario Valenza, and Gloria Pelizzo
Hormone Research in Paediatrics, 2017, Volume 88, Number 3-4, Page 224
[13]
Alaa Al Nofal, Lyndsay D Viers, and Asma Javed
Gynecological Endocrinology, 2017, Page 1
[14]
Cornelis J. de Groot, Adriaan van den Berg, Bart E.P.B. Ballieux, Herman M. Kroon, Edmond H.H.M. Rings, Jan M. Wit, and Erica L.T. van den Akker
Hormone Research in Paediatrics, 2017, Volume 87, Number 4, Page 254
[15]
Jaime Moritz Brum, Isabela Maria Pinto de Oliveira Rizzo, Walquiria Domingues de Mello, and Carlos Eduardo Speck-Martins
Arquivos de Neuro-Psiquiatria, 2008, Volume 66, Number 3a, Page 545
[16]
Fu-Min Wang, Chien-Ming Lin, Shao-Hung Lien, Li-Wei Wu, Ching-Feng Huang, and Der-Ming Chu
Medicine, 2017, Volume 96, Number 19, Page e6834
[17]
[18]
[19]
Marta García, Raquel Barrio, Montserrat García-Lavandeira, Angela R. Garcia-Rendueles, Adela Escudero, Esther Díaz-Rodríguez, Darya Gorbenko Del Blanco, Ana Fernández, Yolanda B. de Rijke, Elena Vallespín, Julián Nevado, Pablo Lapunzina, Vilborg Matre, Patricia M. Hinkle, Anita C. S. Hokken-Koelega, María P. de Miguel, José Manuel Cameselle-Teijeiro, Manuel Nistal, Clara V. Alvarez, and José C. Moreno
Scientific Reports, 2017, Volume 7, Page 42937
[20]
Verena Behringer and Tobias Deschner
Hormones and Behavior, 2017, Volume 91, Page 3
[21]
Kirsten Heussner, Manfred Rauh, Nada Cordasic, Carlos Menendez-Castro, Hanna Huebner, Matthias Ruebner, Marius Schmidt, Andrea Hartner, Wolfgang Rascher, and Fabian B. Fahlbusch
Steroids, 2017, Volume 120, Page 1
[22]
Carmen Ghisleni, Steffen Bollmann, Anna Biason-Lauber, Simon-Shlomo Poil, Daniel Brandeis, Ernst Martin, Lars Michels, Martin Hersberger, John Suckling, Peter Klaver, Ruth L. O'Gorman, and Hengyi Rao
PLOS ONE, 2015, Volume 10, Number 9, Page e0135827
[23]
Yin Ting Cheung, Wassim Chemaitilly, Daniel A. Mulrooney, Tara M. Brinkman, Wei Liu, Pia Banerjee, Deokumar Srivastava, Ching-Hon Pui, Leslie L. Robison, Melissa M. Hudson, and Kevin R. Krull
Psychoneuroendocrinology, 2017, Volume 76, Page 114
[24]
Kiki M.G.J. Wigny, Wendy van Dorp, Anne-Lotte L.F. van der Kooi, Yolanda B. de Rijke, Andrica C.H. de Vries, Marij Smit, Saskia M.F. Pluijm, Erica L.T. van den Akker, Rob Pieters, Joop S.E. Laven, and Marry M. van den Heuvel-Eibrink
Human Reproduction, 2016, Volume 31, Number 11, Page 2613
[25]
Katarzyna Kulej-Lyko, Jacek Majda, Stephan von Haehling, Wolfram Doehner, Monika Lopuszanska, Alicja Szklarska, Waldemar Banasiak, Stefan D. Anker, Piotr Ponikowski, and Ewa A. Jankowska
The Aging Male, 2016, Volume 19, Number 4, Page 221
[26]
Nattawat Ngamsamut, Yaowaluck Hongkaew, Natchaya Vanwong, Pornpen Srisawasdi, Apichaya Puangpetch, Bhunnada Chamkrachangpada, Theerarat Tan-Khum, Penkhae Limsila, and Chonlaphat Sukasem
Basic & Clinical Pharmacology & Toxicology, 2016, Volume 119, Number 3, Page 267
[28]
Chonlaphat Sukasem, Yaowaluck Hongkaew, Nattawat Ngamsamut, Apichaya Puangpetch, Natchaya Vanwong, Montri Chamnanphon, Bhunnada Chamkrachchangpada, Ananya Sinrachatanant, and Penkhae Limsila
Journal of Clinical Psychopharmacology, 2016, Volume 36, Number 2, Page 141
[29]
Mia Elbek Sømod, Esben Thyssen Vestergaard, Kurt Kristensen, and Niels Holtum Birkebæk
International Journal of Pediatric Endocrinology, 2016, Volume 2016, Number 1
[30]
Craig S. Atwood, Sivan Vadakkadath Meethal, Tianbing Liu, Andrea C. Wilson, Miguel Gallego, Mark A. Smith, and Richard L. Bowen
Journal of Neuropathology & Experimental Neurology, 2005, Volume 64, Number 2, Page 93
[31]
Tina T.-C. Tseng, Arwinda Gusviputri, and Le Ngoc Quynh Hoa
Journal of Electroanalytical Chemistry, 2015, Volume 758, Page 59
[32]
Jacalyn Kelly, Joshua E. Raizman, Victoria Bevilacqua, Man Khun Chan, Yunqi Chen, Frank Quinn, Beth Shodin, David Armbruster, and Khosrow Adeli
Clinica Chimica Acta, 2015, Volume 450, Page 196
[33]
Ji Hoon Jung, Youn Seon Choi, Seon Mee Kim, June Young Lee, Eun Hye Kim, Jung Eun Kim, E Yeon Kim, Hee Jin Park, and Dong Jin Yoon
Korean Journal of Hospice and Palliative Care, 2015, Volume 18, Number 2, Page 105
[34]
Venkatachalem Sathish, Yvette N. Martin, and Y.S. Prakash
Pharmacology & Therapeutics, 2015, Volume 150, Page 94
[35]
Matthew Aaron Pettengill, Simon Daniël van Haren, and Ofer Levy
Frontiers in Immunology, 2014, Volume 5
[36]
Annette Rennert, Jürgen Wittsiepe, Monika Kasper-Sonnenberg, Gerhard Binder, Peter Fürst, Claudia Cramer, Ursula Krämer, and Michael Wilhelm
Journal of Toxicology and Environmental Health, Part A, 2012, Volume 75, Number 19-20, Page 1232
[37]
Maya B. Lodish, Evgenia Gourgari, Ninet Sinaii, Suvimol Hill, Laura Libuit, Spyridon Mastroyannis, Margaret Keil, Dalia L. Batista, and Constantine A. Stratakis
The Journal of Pediatrics, 2014, Volume 164, Number 4, Page 801
[38]
M. Schumacher, C. Mattern, A. Ghoumari, J.P. Oudinet, P. Liere, F. Labombarda, R. Sitruk-Ware, A.F. De Nicola, and R. Guennoun
Progress in Neurobiology, 2014, Volume 113, Page 6
[39]
Anju Sukumaran and John Buchlis
Case Reports in Pediatrics, 2013, Volume 2013, Page 1
[40]
Mary E. Saczawa, Julia A. Graber, Jeanne Brooks-Gunn, and Michelle P. Warren
Psychoneuroendocrinology, 2013, Volume 38, Number 11, Page 2815
[41]
K. Suzanne Scherf, Joshua M. Smyth, and Mauricio R. Delgado
Hormones and Behavior, 2013, Volume 64, Number 2, Page 298
[42]
Daniel J. Safer, Chadi A. Calarge, and Alan M. Safer
Journal of Child and Adolescent Psychopharmacology, 2013, Volume 23, Number 4, Page 282
[43]
Rhoda J. Gottfried, Joan P. Gerring, Kyla Machell, Gayane Yenokyan, and Mark A. Riddle
Journal of Child and Adolescent Psychopharmacology, 2013, Volume 23, Number 2, Page 91
[44]
Jessica Raper, Jocelyne Bachevalier, Kim Wallen, and Mar Sanchez
Psychoneuroendocrinology, 2013, Volume 38, Number 6, Page 818
[45]
Y. Roke, P. N. van Harten, J. K. Buitelaar, D. E. Tenback, L. G. B. A. Quekel, Y. B. de Rijke, and A. M. Boot
European Journal of Endocrinology, 2012, Volume 167, Number 6, Page 855
[46]
Ivana Zec, Ivana Kučak, Ilijana Begčević, Ana-Maria Šimundić, Dubravka Tišlarić-Medenjak, Željka Bukovec Megla, and Nada Vrkić
Clinical Biochemistry, 2012, Volume 45, Number 15, Page 1206
[47]
Lourdes Ibáñez Toda and Neus Potau Vilalta
Endocrinología y Nutrición, 2007, Volume 54, Number 3, Page 174
[48]
F.M. Antonini, E. Petruzzi, P. Pinzani, C. Orlando, I. Petruzzi, M. Pazzagli, and G. Masotti
Archives of Gerontology and Geriatrics, 2005, Volume 41, Number 2, Page 151
[49]
Bodo C. Melnik
Medical Hypotheses, 2011, Volume 76, Number 4, Page 553
[50]
Sarah Ordaz and Beatriz Luna
Psychoneuroendocrinology, 2012, Volume 37, Number 8, Page 1135
[51]
Jennifer Osipoff, Robert Peyster, and Thomas A. Wilson
Pediatric Radiology, 2010, Volume 40, Number S1, Page 150
[52]
Keiko Wada, Kozue Nakamura, Yuya Tamai, Michiko Tsuji, Kaori Watanabe, Kyoko Ando, and Chisato Nagata
Cancer Causes & Control, 2012, Volume 23, Number 2, Page 239
[53]
Keiko Wada, Kozue Nakamura, Yuya Tamai, Michiko Tsuji, Takako Masue, Kyoko Ando, and Chisato Nagata
Cancer Causes & Control, 2012, Volume 23, Number 2, Page 231
[54]
Johannes Scherr, Ulrike Geissler, Karl-Heinz Waibel, Katharina Blume, Wolfgang Maier, Martin Halle, and Bernd Wolfarth
Sport-Orthopädie - Sport-Traumatologie - Sports Orthopaedics and Traumatology, 2011, Volume 27, Number 4, Page 239
[56]
Offie P. Soldin, Eve G. Hoffman, Michael A. Waring, and Steven J. Soldin
Clinica Chimica Acta, 2005, Volume 355, Number 1-2, Page 205
[57]
Lise Eliot
Sex Roles, 2013, Volume 69, Number 7-8, Page 363
[58]
Laura R. Stroud, George D. Papandonatos, Douglas E. Williamson, and Ronald E. Dahl
Psychoneuroendocrinology, 2011, Volume 36, Number 8, Page 1226
[59]
Russell D. Romeo
Frontiers in Neuroendocrinology, 2010, Volume 31, Number 2, Page 232
[62]
Offie P. Soldin, Tiedong Guo, Elisabete Weiderpass, Rochelle E. Tractenberg, Leena Hilakivi-Clarke, and Steven J. Soldin
Fertility and Sterility, 2005, Volume 84, Number 3, Page 701
[63]
M. Janfaza, T.I. Sherman, K.A. Larmore, J. Brown-Dawson, and K.O. Klein
Journal of Pediatric Endocrinology and Metabolism, 2006, Volume 19, Number 7
[64]
G. Guercio, M.A. Rivarola, E. Chaler, M. Maceiras, and A Belgorosky
Journal of Pediatric Endocrinology and Metabolism, 2009, Volume 22, Number 3
[65]
Megan Gunnar and Karina Quevedo
Annual Review of Psychology, 2007, Volume 58, Number 1, Page 145
[66]
Mari Ervasti, Sanna Kotisaari, Ulla Sankilampi, Seppo Heinonen, and Kari Punnonen
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 8
[67]
Thu Koskas, Karamo Souaré, Tarik Ouahabi, Dominique Porquet, and Didier Chevenne
Clinical Chemical Laboratory Medicine, 2007, Volume 45, Number 4
[68]
Mari Rehu, Kari Punnonen, Vaughn Ostland, Seppo Heinonen, Mark Westerman, Kari Pulkki, and Ulla Sankilampi
European Journal of Haematology, 2010, Volume 85, Number 4, Page 345
[69]
Laura R. Stroud, Elizabeth Foster, George D. Papandonatos, Kathryn Handwerger, Douglas A. Granger, Katie T. Kivlighan, and Raymond Niaura
Development and Psychopathology, 2009, Volume 21, Number 01, Page 47
[70]
Tiago Degani Veit, Priscilla Vianna, Ilóite Scheibel, Claiton Brenol, João Carlos Tavares Brenol, Ricardo Machado Xavier, Andres Delgado-Cañedo, Jorge Eduardo Gutierrez, Ana Paula Carneiro Brandalize, Lavinia Schuler-Faccini, and José Artur Bogo Chies
Tissue Antigens, 2008, Volume 71, Number 5, Page 440
[71]
Run-Sup Ahn, Young-jin Lee, Jun-Young Choi, Hyuk-Bang Kwon, and Se-il Chun
Yonsei Medical Journal, 2007, Volume 48, Number 3, Page 379
[72]
D. Pfeiffer, J. Berger, C. Schoop, and R. Tauber
Der Urologe, 2008, Volume 47, Number 1, Page 59
[73]
Hamed A. El-Khayat, Fatma Z. Abd El-Basset, Hoda Y. Tomoum, Saeid M. Tohamy, Amira A. Zaky, Mervat S. Mohamed, Suzan M. Hakky, Nancy S. El Barbary, and Nermin M. Nassef
Epilepsia, 2004, Volume 45, Number 9, Page 1106
[74]
K. J. Millar, R. R. Thiagarajan, and P. C. Laussen
Pediatric Cardiology, 2007, Volume 28, Number 3, Page 176
[75]
Bruce J. Ellis
Psychological Bulletin, 2004, Volume 130, Number 6, Page 920
[76]
Nicole R. Nugent, Norman C. Christopher, and Douglas L. Delahanty
Journal of Traumatic Stress, 2006, Volume 19, Number 3, Page 349
[77]
Alison M. Jones and John W. Honour
Clinical Endocrinology, 2006, Volume 64, Number 3, Page 234
[78]
J. C. Wommack, A. Salinas, and Y. Delville
Journal of Neuroendocrinology, 2005, Volume 0, Number 0, Page 051011091534001
[79]
Laurence R. Gesquiere, Jeanne Altmann, Memuna Z. Khan, Jannelle Couret, Jennifer C. Yu, Courtney S. Endres, Jessica W. Lynch, Patrick Ogola, Elizabeth A. Fox, Susan C. Alberts, and Emmanuel O. Wango
American Journal of Primatology, 2005, Volume 67, Number 1, Page 83
[80]
Carla Musso, Thomas Shawker, Elaine Cochran, Edward D. Javor, Janice Young, and Phillip Gorden
Clinical Endocrinology, 2005, Volume 63, Number 1, Page 73
[81]
Katrine Bay, Anna-Maria Andersson, and Niels E. Skakkebaek
International Journal of Andrology, 2004, Volume 27, Number 5, Page 266

Comments (0)

Please log in or register to comment.
Log in