Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

12 Issues per year

IMPACT FACTOR 2016: 3.432

CiteScore 2016: 2.21

SCImago Journal Rank (SJR) 2016: 1.000
Source Normalized Impact per Paper (SNIP) 2016: 1.112

See all formats and pricing
More options …
Volume 40, Issue 12


Nutritional Regulation of Visceral Markers in Rat Liver and Cultured Hepatoma Cells

Daniel S. Straus
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2002.221


Protein malnutrition in humans and other animals is consistently associated with a decreased concentration of circulating serum albumin, transthyretin (TTR), and insulin-like growth factor-I (IGF-I). The molecular mechanisms for regulation of the three polypeptides by dietary protein remain to be completely elucidated. The abundance of albumin, TTR and IGF-I mRNA is decreased in liver of juvenile rats consuming insufficient amounts of protein. Moreover, protein restriction specifically decreases the abundance of albumin and TTR nuclear transcripts, indicating that the reduction in mRNA levels for these two genes is caused at least partly by a decrease in gene transcription. Expression of several other genes transcribed at a high level in the liver is also decreased under conditions of dietary protein restriction, suggesting that the level/functional activity of liver-enriched transcription factor(s) might be decreased under these conditions. Limitation of cultured hepatoma cells for a single amino acid also selectively decreases the mRNA levels of several genes with liver-enriched expression, including albumin and TTR. The decrease in albumin mRNA is caused partly by decreased albumin gene transcription and partly by destabilization of albumin mRNA.

About the article

Published Online: 2005-06-01

Published in Print: 2002-12-10

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 40, Issue 12, Pages 1274–1280, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.221.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Jim Kaput, Alla Perlina, Betul Hatipoglu, Amelia Bartholomew, and Yuri Nikolsky
Pharmacogenomics, 2007, Volume 8, Number 4, Page 369
Minhua Li, Bo Ye, Yuxia Zhang, Honglei Chen, Dong Xia, Mingqiu Liu, and Fei Yang
Journal of Biomedicine and Biotechnology, 2009, Volume 2009, Page 1
Anne-Kristin Fentz, Monika Spörl, Jörg Spangenberg, Heinz Joachim List, Carsten Zornig, Arnulf Dörner, Peter Layer, Hartmut Juhl, and Kerstin A. David
PROTEOMICS – Clinical Applications, 2007, Volume 1, Number 6, Page 536

Comments (0)

Please log in or register to comment.
Log in