Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

249,00 € / $374.00 / £187.00*

See all formats and pricing


Select Volume and Issue


30,00 € / $42.00 / £23.00

Get Access to Full Text

Observations with Regard to the National Kidney Foundation K/DOQI Clinical Practice Guidelines Concerning Serum Transthyretin in Chronic Renal Failure

Joel D. Kopple / Rajnish Mehrotra / Oppatham Suppasyndh / Kamyar Kalantar-Zadeh

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 12, Pages 1308–1312, ISSN (Print) 1434-6621, DOI: 10.1515/CCLM.2002.225, June 2005

Publication History

Published Online:


The National Kidney Foundation K/DOQI Guidelines state that, “Serum prealbumin is a valid and clinically useful measure of protein-energy nutritional status in maintenance dialysis (MD) patients.” Prealbumin, also known as serum transthyretin (TTR), was not recommended as a nutritional parameter of the same usefulness as the serum albumin. This decision was made, in part, because published research at that time suggested that serum TTR was not a more sensitive index of nutritional status than serum albumin and there was much more clinical and research experience with serum albumin as a nutritional and inflammatory marker. Evidence, including more recently published research data, which is reviewed in this paper has led to the following conclusions by the current authors: 1) In MD patients either protein-energy malnutrition or inflammation can lead to a reduction in serum TTR concentrations. 2) Hence, in MD patients, serum TTR concentrations can be used as a measure of both nutritional and inflammatory status. 3) Serum TTR concentrations are typically increased in MD patients. 4) In maintenance hemodialysis (MHD) patients, serum TTR is a risk factor for mortality that is somewhat independent of serum albumin. 5) Current epidemiological evidence suggests that a serum TTR value of 25 or 30 mg/dl or greater is associated with increased survival and, hence, is desirable in MHD patients. 6) MHD patients with serum TTR levels less than 25–30 mg/dl should be evaluated for protein-energy malnutrition and inflammation.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

A. Henze, K. M. Espe, C. Wanner, V. Krane, J. Raila, B. Hocher, F. J. Schweigert, and C. Drechsler
Diabetes Care, 2012, Volume 35, Number 11, Page 2365
Jeannette M. Beasley and Judith Wylie-Rosett
Current Atherosclerosis Reports, 2013, Volume 15, Number 9
Rizwana Batool, Masood Sadiq Butt, Muhammad Tauseef Sultan, Farhan Saeed, and Rabia Naz
Critical Reviews in Food Science and Nutrition, 2015, Volume 55, Number 2, Page 242
Csaba P. Kovesdy and Kamyar Kalantar-Zadeh
Seminars in Dialysis, 2012, Volume 25, Number 4, Page 423
Bin Zhang, Cong Gao, Qinghua Hou, Jianrui Yin, Longchang Xie, Shuxiang Pu, Yonghong Yi, and Qingchun Gao
Journal of Neurology, 2012, Volume 259, Number 7, Page 1420
Hayet Fellah, Souheil Omar, Moncef Feki, Ezzedine Abderrahim, Taieb Ben Abdallah, Ziad A. Massy, Bernard Lacour, Hedi Ben Maiz, Neziha Kaabachi, and Abderraouf Mebazaa
Clinical Biochemistry, 2008, Volume 41, Number 7-8, Page 493
Simone K. Frey, Andrea Henze, Britta Nagl, Jens Raila, Alexandra Scholze, Martin Tepel, Florian J. Schweigert, and Walter Zidek
Clinica Chimica Acta, 2009, Volume 401, Number 1-2, Page 46
Kamyar Kalantar-Zadeh, T.Alp Ikizler, Gladys Block, Morrel M. Avram, and Joel D. Kopple
American Journal of Kidney Diseases, 2003, Volume 42, Number 5, Page 864
Cong Gao, Bin Zhang, WeiZhi Zhang, ShuXiang Pu, JianRui Yin, and QingChun Gao
Clinical and Experimental Medicine, 2011, Volume 11, Number 1, Page 49
Wang Jianqing, Dai Yong, Deng Anguo, and Liu Jianjun
Journal of Huazhong University of Science and Technology [Medical Sciences], 2005, Volume 25, Number 5, Page 604
D Fouque, K Kalantar-Zadeh, J Kopple, N Cano, P Chauveau, L Cuppari, H Franch, G Guarnieri, T A Ikizler, G Kaysen, B Lindholm, Z Massy, W Mitch, E Pineda, P Stenvinkel, A Trevinho-Becerra, and C Wanner
Kidney International, 2008, Volume 73, Number 4, Page 391

Comments (0)

Please log in or register to comment.