Jump to ContentJump to Main Navigation
Show Summary Details

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

IMPACT FACTOR increased in 2015: 3.017
Rank 5 out of 30 in category Medical Laboratory Technology in the 2014 Thomson Reuters Journal Citation Report/Science Edition

SCImago Journal Rank (SJR) 2015: 0.873
Source Normalized Impact per Paper (SNIP) 2015: 0.982
Impact per Publication (IPP) 2015: 2.238

See all formats and pricing


Select Volume and Issue


Intermethod Variation in Serum Carcinoembryonic Antigen (CEA) Measurement. Fresh Serum Pools and Control Materials Compared

Roberto Dominici / Enrico Cabrini / Giampaolo Cattozzo / Ferruccio Ceriotti / Vittorio Grazioli / Luisa Scapellato / Carlo Franzini

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 2, Pages 167–173, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.029, June 2005

Publication History

Published Online:


This study was undertaken to evaluate the feasibility of using commercial control materials in a regional external quality assessment scheme (EQAS) for serum carcinoembryonic antigen (CEA) measurement. We have assessed the commutability of 12 commercial control materials using five automated immunochemical systems. We compared the intermethod behavior of the materials with that of 12–14 patient serum pools. In a total of 48 comparisons (12 materials × 4 pairs of analytical systems), seven instances of noncommutability were apparent, as shown by normalized residuals falling outside the ±3 interval. The use of non-commutable materials generates two negative effects. In EQAS, the interlaboratory variation recorded is not representative of the variation expected in the assay of patient sera; in interlaboratory harmonization programs, recalibration with non-commutable materials increases, instead of decreasing, the interlaboratory variation. Both these effects were shown to occur in CEA measurement with the tested materials and systems. The materials planned to be used in our EQAS turned out to be commutable: this gave us the guarantee of measuring realistic interlaboratory variation values, although the check for commutability should be extended to all the analytical systems used by the participants in the scheme.

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Mauro Panteghini
Clinical Chemistry and Laboratory Medicine, 2004, Volume 42, Number 1
Jacqueline R Cohen, Joan I Schall, Richard F Ittenbach, Babette S Zemel, and Virginia A Stallings
Journal of Pediatric Gastroenterology and Nutrition, 2005, Volume 40, Number 4, Page 438

Comments (0)

Please log in or register to comment.