Jump to ContentJump to Main Navigation
Show Summary Details
More options …

Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2017: 3.556

CiteScore 2017: 2.34

SCImago Journal Rank (SJR) 2017: 1.114
Source Normalized Impact per Paper (SNIP) 2017: 1.188

See all formats and pricing
More options …
Volume 40, Issue 3


Evaluation of Two Mg2+-Selective Electrodes by Means of a Flow-Through Device

Frank H. Boguschewski / Michael Seyfarth / Jens P. Heidrich
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2002.049


Monitoring the ionized magnesium (Mg2+) concentration in critically ill patients can prevent development of serious and potentially fatal complications. The analyzers KONE Microlyte 6 (KONE Instruments, Espoo, Finland) and NOVA CRT (NOVA Biomedical, Waltham, MA, USA) provide the discontinuous measurement of Mg2+ and were evaluated in several studies. It was our objective to integrate the Mg2+-selective electrodes into a device for continuous on-line measurements. This device is suitable not only for research but also for a specific evaluation of electrode characteristics. It allowed us to compare the genuine electrodes and reference systems independently of their specific analyzers. Precision, accuracy, response time, limit of detection, drift and interferences were assessed by continuous flow-through measurements and discussed in comparison to the results of previous studies. The NOVA electrode proved to be superior regarding accuracy, sensitivity and selectivity, especially with respect to calcium. It was demonstrated that current commercial serum-like control materials were not appropriate for quality control of the assessed Mg2+-electrodes. However, despite the fact that the electrodes are commercially used for discontinuous measurements, both sensor types can be used for continuous on-line measurements in an extracorporeal circulation in a rat model. The NOVA electrode showed superior characteristics with this application as well. This study should also be understood as a contribution to the development of devices for on-line analyzers used in point-of-care-testing.

About the article

Published Online: 2005-06-01

Published in Print: 2002-04-10

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 40, Issue 3, Pages 308–311, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.049.

Export Citation

Citing Articles

Here you can find all Crossref-listed publications in which this article is cited. If you would like to receive automatic email messages as soon as this article is cited in other publications, simply activate the “Citation Alert” on the top of this page.

Goce Dimeski, Tony Badrick, and Andrew St John
Clinica Chimica Acta, 2010, Volume 411, Number 5-6, Page 309

Comments (0)

Please log in or register to comment.
Log in