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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

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Ed. by Gillery, Philippe / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter / Tate, Jillian R.

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Reference Values for a Heterogeneous Ferritin Assay and Traceability to the 3rd International Recombinant Standard for Ferritin (NIBSC Code 94/572)

Ahmad Hamwi / Georg Endler / Karl Rubi / Oswald Wagner / Arno Thomas Endler

Citation Information: Clinical Chemistry and Laboratory Medicine. Volume 40, Issue 4, Pages 365–370, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.059, June 2005

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Reference values for Ferritin FlexTM on the Dimension RxL analyzer calibrated against the 3rd International Standard for Ferritin (recombinant) and N-Latex Ferritin ® on the BNA II nephelometer calibrated against the 2nd International Standard for Ferritin (spleen) both from Dade Behring (Marburg, Germany) were established (77 men and 182 women). Exclusion criteria were iron deficiency or iron deficiency anemia, inflammation, liver disease, malignancy, and other hematological or chronic disorders. The reference values (5.0th–95th percentiles) were as follow: for N-Latex Ferritin® –men, 12–399 μg/l; women <50 years, 11–102 μg/l and women ≥50 years, 17–219 μg/l; for Ferritin FlexTM –men, 14–415 μg/l; women <50 years, 11–111 μg/l and women ≥50 years, 22–224 μg/l. Both assays correlated very closely with each other (r=0.993). The linearity was acceptable down to 2 μg/l for the Ferritin FlexTM method, but only down to 15 μg/l for the N-Latex Ferritin® assay. The mean recovery of the 3rd International Standard by N-Latex Ferritin® and Ferritin FlexTM was comparable (~80%). We conclude that the new Ferritin FlexTM assay, which is based on the new 3rd International Standard, should be used for ferritin measurement in the routine medical laboratories in the future.

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