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Clinical Chemistry and Laboratory Medicine (CCLM)

Published in Association with the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM)

Editor-in-Chief: Plebani, Mario

Ed. by Gillery, Philippe / Greaves, Ronda / Lackner, Karl J. / Lippi, Giuseppe / Melichar, Bohuslav / Payne, Deborah A. / Schlattmann, Peter

IMPACT FACTOR 2018: 3.638

CiteScore 2018: 2.44

SCImago Journal Rank (SJR) 2018: 1.191
Source Normalized Impact per Paper (SNIP) 2018: 1.205

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Volume 40, Issue 5


The Effect of N-Acetylcysteine Supplementation upon Viral Load, CD4, CD8, Total Lymphocyte Count and Hematocrit in Individuals Undergoing Antiretroviral Treatment

Celso Spada / Arício Treitinger / Marcellus Reis / Ivete Y. Masokawa / Júlio C. Verdi / Magali C. Luiz / Mariete V.S. Silveira / Cleonice M. Michelon / Sílvio Ávila-Junior / Ione D.O. Gil / Stephanie Ostrowsky
Published Online: 2005-06-01 | DOI: https://doi.org/10.1515/CCLM.2002.077


Individuals infected with the human immunodeficiency virus (HIV-1) present with decreased CD4, a progressive increase in viral load, compromised cell immune defense, and hematologic alterations. The aim of this study was to assess the serum viral load, CD4, CD8, lymphocyte count and hematocrit at the beginning of antiretroviral therapy in individuals who were supplemented with N-acetylcysteine (NAC). Twenty volunteers participated in this double-blind, placebocontrolled 180-day study. Ten participants received 600 mg of NAC per day (NAC group) and the other ten serving as a control group received placebo. The above mentioned parameters were determined before treatment, and after 60, 120 and 180 days. In NAC-treated patients hematocrit remained stable and an increase in CD4 cell count took place earlier than that in the control group.

About the article

Published Online: 2005-06-01

Published in Print: 2002-06-06

Citation Information: Clinical Chemistry and Laboratory Medicine, Volume 40, Issue 5, Pages 452–455, ISSN (Print) 1434-6621, DOI: https://doi.org/10.1515/CCLM.2002.077.

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